Browse our latest Structural Biology and Molecular Biophysics articles

Switches in cell state downstream of pathogen exposure are driven by a deeply conserved disorder-to-order phase transition in an immunity signaling network.

The spider venom peptide Pn3a recognizes a pharmacophore unique to Ca_V3.3 amongst T-type calcium channels, underscoring its potential as a novel molecular tool for the study of Ca_V3.3-mediated currents in native cells.

For analyzing time-dependent patch-clamp or patch-clamp fluorometry data of ion channels in terms of Markovian models, the superiority of Bayesian filtering with respect to traditional deterministic approaches is demonstrated enabling more reliable quantification of the parameters.

The entry glycoproteins of hepatitis C virus, E1E2, possess a novel regulatory mechanism in which protein disorder is harnessed to control their activity and their ability to evade antibodies.

A combination of single-molecule and in vivo FRET showed how drugs affect conformation of mGluR2 at different domains.

Structural, biochemical, and cellular data reveal the mechanism by which the clamp loader attaches sliding clamps at gapped and nicked DNA to support DNA damage repair.

Biochemical studies in combination with computational modeling and molecular dynamics simulations reveal that the lipid bilayer promotes intramembrane proteolysis by stabilizing the enzyme-substrate complex and the protease active site.

Mg²⁺-dependent JAK1-mediated phosphorylation sensitizes TRPV2 activity and thermo-threshold, which is counterbalanced by PTPN1-mediated dephosphorylation, highlighting a role of phosphorylation homeostasis in setting the basal activity of TRPV2.

By measuring the impacts of thousands of mutations on potassium channel trafficking and function, we illuminate the molecular basis of folding, structure–function relationships, and how these are altered in disease.

A mitochondrial membrane-bound protein ATAD1 uses conserved structural elements to remove mislocalized membrane proteins from the outer mitochondrial membrane, achieving proper cell organization.