Browse our latest Structural Biology and Molecular Biophysics articles

The majority of TMEM16 lipid scrambling occurs in the open groove associated with Ca²⁺ activation, but limited scrambling also occurs in the dimer interface independent of Ca²⁺.

A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.

The cryo-EM structures of a pentameric ligand-gated ion channel in liposomes, an environment that supports ion channel function, are different than structures in lipid nanodiscs.

The architectures of human PIEZO1 and its slow-inactivating channelopathy mutants with or without its auxiliary subunit MDFIC reveal the inactivation mechanism of PIEZO channels.

Customized AlphaFold-based modeling of distinct functional states of the hERG channel, a major drug anti-target, significantly improves drug affinity predictions, enhancing cardiac safety screening for arrhythmia risk.

Polyphosphate, a universal stress response regulator, binds distinctively to different starting ensembles of the same protein leading to either condensates or aggregates that in turn can solubilize or further aggregate, showcasing their ability to finely control the assembly process.