Browse our latest Structural Biology and Molecular Biophysics articles

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    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Unbend: Correction of local beam-induced sample motion in cryo-EM images using a 3D spline model

    Lingli Kong, Ximena Zottig ... Nikolaus Grigorieff
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation

    Takashi Hotta, Morgan L Pimm ... Kristen J Verhey
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations

    Gabriel Monteiro da Silva, Kyle Lam ... Brenda M Rubenstein
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

    Siyu Chen, Tamar Basiashvili ... Elizabeth Villa
    Full-length, autoinhibited LRRK2 assembles into distinct, shorter microtubule-bound filaments via a previously unobserved N-terminal repeat interface, revealing new structural states with potential therapeutic implications.
    Version of Record
    Short Report
    • Important
    • Convincing
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Cryo-EM Reveals Regulatory Mechanisms Governing Substrate Selection and Activation of Human LONP1

    Jeffrey T Mindrebo, Lauren Alexandrescu ... Gabriel C Lander
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase

    Omar Herrera-Asmat, Alexander B Tong ... Carlos Bustamante
    Optical tweezers are used to gain mechanistic insight in the mechanism of inhibition of three distinct compounds being developed as antibiotics against Mycobacterium tuberculosis.
    1. Structural Biology and Molecular Biophysics

    Structure of the human CTF18−RFC clamp loader bound to PCNA

    Giuseppina R Briola, Muhammad Tehseen ... Alfredo De Biasio
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Molecular Architecture and Function Mechanism of Tri-heteromeric GluN1-N2-N3A NMDA Receptors

    Zengwei Kou, Fenyong Yao ... Yidi Sun
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure revealed a novel F-actin binding motif in a Legionella pneumophila lysine fatty-acyltransferase

    Wenjie W Zeng, Garrison Komaniecki ... Yuxin Mao
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Decoding molecular mechanisms for loss-of-function variants in the human proteome

    Matteo Cagiada, Nicolas Jonsson, Kresten Lindorff-Larsen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Solid
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