Browse our latest Structural Biology and Molecular Biophysics articles

Page 4 of 160
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin–antitoxin system

    René L Bærentsen, Stine V Nielsen ... Ditlev E Brodersen
    Structural analysis of the HipBST toxin–antitoxin system from E. coli shows how a toxin kinase has been split into two proteins and encodes its own inhibitor.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Vibrio cholerae’s ToxRS bile sensing system

    Nina Gubensäk, Theo Sagmeister ... Tea Pavkov-Keller
    The sensory regulatory system of the cholera causative involves the detection of bile acids by direct interaction with the inner membrane protein complex formed by ToxR and ToxS, thereby inducing concentration-dependent structural changes.
    1. Structural Biology and Molecular Biophysics

    Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

    Tej Kandola, Shriram Venkatesan ... Randal Halfmann
    The disease-associated aggregation of polyglutamine begins in a single molecule with a specific structure.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Myristoyl’s dual role in allosterically regulating and localizing Abl kinase

    Svenja de Buhr, Frauke Gräter
    The cellular membrane competes with Abl for myristoyl binding to stabilize the preactivated state and enhance allosteric activation.
    1. Cancer Biology
    2. Structural Biology and Molecular Biophysics

    The molecular basis of Abelson kinase regulation by its αI-helix

    Johannes Paladini, Annalena Maier ... Stephan Grzesiek
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Autoinhibited kinesin-1 adopts a hierarchical folding pattern

    Zhenyu Tan, Yang Yue ... Michael A Cianfrocco
    Modular folding of kinesin-1 motor proteins enables a fully autoinhibited state.
    1. Structural Biology and Molecular Biophysics

    Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect akuBGL activity

    Xiaomei Sun, Yuxin Ye ... Min Yao
    A structural and biochemical study reveals the molecular mechanism of the predator–prey associations of Aplysia kurodai and brown algae (akuBGL–phlorotannin/laminarin–EHEP system), which has high-potential applications in the biotechnology industry.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular tuning of sea anemone stinging

    Lily S He, Yujia Qi ... Nicholas W Bellono
    Sea anemones use adapted ion channels to control stinging behavior.