Browse our latest Structural Biology and Molecular Biophysics articles

Page 4 of 169
    1. Structural Biology and Molecular Biophysics

    Ais: streamlining segmentation of cryo-electron tomography datasets

    Mart G.F. Last, Leoni Abendstein ... Thomas H. Sharp
    1. Structural Biology and Molecular Biophysics

    Automated multiconformer model building for X-ray crystallography and cryo-EM

    Stephanie A Wankowicz, Ashraya Ravikumar ... James S Fraser
    Creating structural models with multiple conformations of proteins improves the fit of the model to experimental data X-ray crystallography and improve the model geometry.
    1. Structural Biology and Molecular Biophysics

    Structural features of heteromeric channels composed of CALHM2 and CALHM4 paralogs

    Katarzyna Drożdżyk, Martina Peter, Raimund Dutzler
    Structural studies revealing the organization of assemblies consisting of CALHM2 and CALHM4 subunits provide insight into the mechanism of heteromerization of large pore channels.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural analysis of the dynamic ribosome-translocon complex

    Aaron JO Lewis, Frank Zhong ... Ramanujan S Hegde
    A combination of cryo-electron microscopy, structure prediction, and evolutionary analyses reveal several functional states of the dynamic protein translocation machinery at the mammalian endoplasmic reticulum.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase

    Roberto Efraín Díaz, Andrew K Ecker ... James S Fraser
    Biochemical and structural investigations of the pH adaptability of mouse Acidic Mammalian Chitinase offer insights for designing enhanced enzyme variants that can function in both lung and gut.
    1. Structural Biology and Molecular Biophysics

    PUFA stabilizes a conductive state of the selectivity filter in IKs channels

    Alessia Golluscio, Jodene Eldstrom ... H. Peter Larsson
    1. Structural Biology and Molecular Biophysics

    Martinize2 and Vermouth: Unified Framework for Topology Generation

    PC Kroon, F Grunewald ... SJ Marrink
    1. Structural Biology and Molecular Biophysics

    Role of N343 glycosylation on the SARS-CoV-2 S RBD structure and co-receptor binding across variants of concern

    Callum M Ives, Linh Nguyen ... Elisa Fadda
    Viral evolution can lead to mutations that render specific glycosylation sites dispensable for folding and for supporting the protein's function, allowing changes in the shield, and in the immunogenic profile.