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    1. Structural Biology and Molecular Biophysics

    Crossover in aromatic amino acid interaction strength between tyrosine and phenylalanine in biomolecular condensates

    David De Sancho, Xabier Lopez
    Hydration modulates aromatic interactions, explaining why Tyr is a stronger sticker than Phe in aqueous environments like protein condensates but not in the cores of folded proteins.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

    Samantha J Cassell, Weiyan Li ... Jonathan R Whicher
    Cryo-EM and electrophysiology reveal the mechanism of SK2 channel modulation by the bee toxin apamin and small molecules, providing insights that enable the rational design of targeted SK2 channel therapeutics.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Natural xanthones as α-Mangostin induce vasorelaxation via binding to key gating residues in the S6 domain of BK channels

    Sönke Cordeiro, Robert Patejdl ... Marianne Musinszki
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Dissecting Mechanisms of Ligand Binding and Conformational Changes in the Glutamine-Binding Protein

    Zhongying Han, Sabrina Panhans ... Thorben Cordes
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

    Jordan M Mancl, Wenguang G Liang ... Wei-Jen Tang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Conduction pathway for potassium through the Escherichia coli pump KdpFABC

    Adel Hussein, Xihui Zhang ... David L Stokes
    The path of potassium through an ATP-dependent membrane pump is elucidated with a high-resolution structure within a lipid bilayer together with mutational analysis at key points along this pathway.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis

    Marie Shimogawa, Ming-Hao Li ... E James Petersson
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Multi-barrier unfolding of the double-knotted protein, TrmD–Tm1570, revealed by single-molecule force spectroscopy and molecular dynamics

    Fernando Bruno da Silva, Szymon Niewieczerzal ... Joanna I Sulkowska
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Protein-Induced Membrane Strain Drives Supercomplex Formation

    Maximilian C Pöverlein, Alexander Jussupow ... Ville RI Kaila
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases

    Jianing Liu, Anokhi Shah ... Keni Vidilaseris
    Distinct asymmetric states in membrane-bound pyrophosphatases reveal how inhibitors block their activity and inform drug development.
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