Browse our latest Structural Biology and Molecular Biophysics articles

Faster ligand-binding kinetics of integrin low-affinity states suggests that integrin binding to ligand and intracellular adapters and the actin cytoskeleton precedes their stabilization, together with tensile force, of the high-affinity, extended-open integrin conformation.

Cholesterol exhibits transient interaction with A2AR and regulates receptor conformational equilibria through indirect membrane effects.

The creation of synthetic cells and organelles will open doors to new collaborative and funding opportunities.

Cryo-EM analysis of full-length human epidermal growth factor receptor provides a molecular explanation for how ligand-induced differential effect in the ligand-binding extracellular module tunes the transmembrane signaling mediated by epidermal growth factor receptor.

Asp234 is deprotonated in the ground state and forms the proton transfer pathway that proceeds from the Schiff base toward Glu68 in the intermediate state of the anion channelrhodopsin GtACR1.

Uniform diameter and curvature of the outer membrane extensions and vesicles of Shewanella oneidensis are maintained by a bacterial Bin/Amphiphysin/Rvs (BAR) domain-like protein BdpA.

The striking reduction in open probability of CFTR channels harboring the R117H cystic fibrosis mutation is caused by loss of a strong hydrogen bond between positions 117 and 1124, which is formed in wild-type channels selectively in the open state.

Biochemical and structural investigations of the human tRNA ligase complex reveal the details of its molecular assembly and provide insights into the reaction mechanism of its catalytic subunit.

Unidirectional crosstalk occurs between signaling competent EGFR dimers activating RON within heteromeric complexes at the plasma membrane.

Single-molecule FRET measurements and protein crosslinking reveal the compact structure of quiescent STIM1 and the conformational rearrangements that enable it to activate store-operated calcium entry.