Browse our latest Structural Biology and Molecular Biophysics articles

Structural and functional analysis reveals the mechanistic basis for mammalian target of rapamycin (mTOR)-dependent roles of DEP domain-containing mTOR interacting protein (DEPTOR) in cancer and metabolic regulation.

A comprehensive functional analysis of mitochondrial Ca²⁺ uniporter (MCU) demonstrates that the auxiliary MICU subunits potentiate Ca²⁺ transport via MCU.

Chaperones from different families and classes synergistically target different stages of tau aggregation, thus preventing pathological amyloid formation.

The nature of the phycobilisome–photosystem II supercomplex on the native thylakoid determined with cryo-electron tomography at an unprecedented resolution reveals that one phycobilisome interconnects with six photosystem monomers.

The necessity of studying extremophile organisms is exemplified by the structure of photosystem I from a high-light tolerant cyanobacteria, demonstrating the relationship between the structure and function in photosystem I.

NmMetQ is a lipoprotein that tethers to membranes via a lipid anchor and has dual function and localization, playing a role in NmMetNI-mediated transport at the inner membrane and moonlighting on the bacterial surface.

SARS-CoV-2 entry mechanism through membrane fusion is regulated by the spike protein glycosylation state.

EphA2 receptor clustering enhances signaling transductions by increasing receptor phosphorylation and binding dwell time of downstream molecules in living cells.

Cryo-EM structure of human TMEM120A reveals that it is a coenzyme A-binding protein and is unlikely to function as a mechanosensitive channel as was recently proposed.

Electrophysiological and structural data do not support a mechanosensitive channel function for TACAN.