Browse our latest Structural Biology and Molecular Biophysics articles

Structural and functional analysis of a new class of low-molecular-weight antibody fragments, derived from bovine immunoglobulins, reveals their therapeutic potential against C5, a target for refractory inflammatory diseases.

The c-terminus of PI3K plays a key role in regulating kinase activity, with c-terminal disease-linked mutations leading to either activation or inhibition, which reveal a path to specific inhibitors.

The primer extension and 5' flap processing activities of DNA polymerase I are physically coordinated by combined movements of the DNA substrate and the 5' nuclease domain of the enzyme.

A chain of residues connecting the voltage sensing domain and the pore domain is responsible for a noncanonical communication between these domains.

SARS-CoV-2 spike protein binding to receptor angiotensin-converting enzyme 2 allosterically enhances furin proteolysis at distal S1/S2 cleavage sites.

The structures of ABCA4 in two conformations provide a framework to understand its transport mechanism.

Heterochromatin proteins compartmentalize DNA into compact structures resistant to mechanical disruption but susceptible to competitive dissolution.

Rudimentary cross-catalytic replication can be established by double-hairpins of tRNA-like sequences, implying that replication and translation could have emerged along a common evolutionary trajectory.

Discovery and characterisation of a novel allosteric inhibitor-binding site in human Bloom syndrome protein.

The results here show that Stu2 binds kinetochores by associating with the Ndc80 complex and that the interaction is critical for accurate chromosome segregation during cell division.