In situ structural analysis of bacterial flagellar motor in the Lyme disease spirochete reveals novel conformational change driven by proton motive force.
TMEM206 proteins are identified as constituting the pore of the widely expressed acid-activated chloride channel PAORAC/ASOR, which is important in acid toxicity.
Hans Moldenhauer, Ignacio Díaz-Franulic ... David Naranjo
Detection of unbinding transitional states in the charybdotoxin first-order dissociation from a Kv-channel reveals that the bound neurotoxin wobbles, suggesting diverse intermediates and dissociation pathways in this protein–protein interaction.
The cryo-EM structure and functional characterization of the chloride-selective ion transporter Slc26a9 defines its oligomeric architecture and transport mechanism.
Hydrogen-deuterium exchange mass spectrometry reveals nucleotide-driven conformational regulation of Sec protein-channel to help impose directionality for protein transport through the Sec complex.
Relion was used to solve structures of microtubules decorated with dynein microtubule-binding domains revealing that an axonemal dynein distorts the microtubule cross-sectional curvature.
The structure of a light-sensitive G protein-coupled receptor in complex with a Gi-protein heterotrimer provides a structural foundation for the role of the receptor C-terminal tail in scaffolding and signaling.
Vivekanandan Shanmuganathan, Nina Schiller ... Roland Beckmann
Two integrated approaches shed light on how XBP1 arrest peptide induces intermediate level of translational pausing and identify hotspot positions to make it stronger.
Mohammed Jamshad, Timothy J Knowles ... Damon Huber
The interaction of SecA with its substrate proteins is regulated by its evolutionarily conserved C-terminal tail, which autoinhibits SecA unless SecA binds to the ribosome.
