Patrick Brandt, Dawayne Whittington ... Rebekah L Layton
Internship programs for PhD and postdoctoral trainees are challenging to develop and sustain, but the benefits to interns and other stakeholders are significant and worth the effort and expense.
A computational systems biology approach identifies a gene network module associated with single-cell mechanical phenotype changes across diverse mouse and human systems, with implications for on-demand engineering of cell stiffness.
Vivian C Salgueiro-Toledo, Jorge Bertol ... Rafael Prados-Rosales
Genetic, ultrastructural, multi-omics, and biochemical tools reveal VirR as a central scaffold in Mycobacterium tuberculosis cell envelope remodelling, critical for extracellular vesicle production.
The observation that an additional vaccine dose provides protection against Omicron variant reinfection in previously vaccinated and infected individuals will help guide future COVID-19 vaccination policies in China and globally.
Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.
Ana Fló, Lucas Benjamin ... Ghislaine Dehaene-Lambertz
Human neonates process regularities in speech's phonetic and voice content in parallel, but only phonetic regularities evoke a specific ERP component in a post-learning phase.
Predictive pharmacology based on behavioural fingerprinting can identify druggable pathways that are altered or renormalized in zebrafish larvae that harbor mutations in early and late-onset Alzheimer's disease risk genes.
Gabriella O Estevam, Edmond Linossi ... James S Fraser
A deep mutational scan of MET kinase domain variants reveals resistance and sensitizing mutations for 11 inhibitors, providing a mutation-specific reference for precision therapies and drug development.
