Browse our latest research

Page 162 of 1,838
    1. Neuroscience

    Single neurons and networks in the mouse claustrum integrate input from widespread cortical sources

    Andrew M Shelton, David K Oliver ... Adam Max Packer
    The claustrum integrates and redistributes sensory and frontal cortical inputs across distinct neural modules to enhance sensitivity to multimodal stimuli.
    1. Physics of Living Systems

    Physical constraints and biological regulations underlie universal osmoresponses

    Yiyang Ye, Qirun Wang, Jie Lin
    Theoretical modeling uncovers an unusual acceleration in microbial growth following osmotic shock, driven by the coordinated regulation of osmolyte production and cell-wall synthesis.
    1. Cell Biology
    2. Neuroscience

    The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after stroke

    Tingbo Li, Ling Yang ... Jie-Min Jia
    Changes in the pericyte pool after stroke affect the restoration of the blood-brain barrier function and brain self-repair, and offer a new approach to therapy.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes

    Vikram Dalal, Brandon K Tan ... Wayland WL Cheng
    The cryo-EM structures of a pentameric ligand-gated ion channel in liposomes, an environment that supports ion channel function, are different than structures in lipid nanodiscs.
    1. Neuroscience

    Heron, a Knowledge Graph editor for intuitive implementation of Python-based experimental pipelines

    George Dimitriadis, Ella Svahn ... Athena Akrami
    A Python-based, open source, GUI application for straightforward development and execution of scientific experiments over multiple machines.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Real-time transcriptomic profiling in distinct experimental conditions

    Tamer Butto, Stefan Pastore ... Susanne Gerber
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Convincing
    1. Cell Biology
    2. Developmental Biology

    Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells

    Robert N Rainey, Sam D Houman ... Neil Segil
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics
    2. Medicine

    EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis

    Lianlei Wang, Xinyu Yang ... Nan Wu
    EPHA4 pathway dysfunction causes axon pathfinding defects, resulting in impaired coordinated left-right locomotion by disrupting neural patterning and the function of central pattern generators, thereby potentially leading to idiopathic scoliosis.
    1. Cell Biology
    2. Developmental Biology

    Female-germline specific protein Sakura interacts with Otu and is crucial for germline stem cell renewal and differentiation and oogenesis

    Azali Azlan, Li Zhu, Ryuya Fukunaga
    Sakura is expressed in female germlines, interacts with Otu, and is crucial for germline stem cell renewal and differentiation and oogenesis in Drosophila.
    1. Immunology and Inflammation

    Opposing regulation of TNF responses by IFN-γ and a PGE2-cAMP axis that is apparent in rheumatoid and immune checkpoint inhibitor-induced arthritis human IL-1β+ macrophages

    Upneet K Sokhi, Ruoxi Yuan ... Lionel B Ivashkiv
    Interferon-γ and prostaglandin E2 signaling oppose each other to determine the balance between two distinct TNF-induced inflammatory gene expression programs relevant for rheumatoid and immune checkpoint inhibitor-induced arthritis.