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Bacterial location quantifications highlights how Drosophila melanogaster larvae discriminate bacteria to isolate and later eliminate pathogens in the anterior midgut through coordinated mechanisms involving reactive oxygen species (ROS) and antimicrobial peptides (AMPs).

The USP-50/USP8 protease removes the Rab5 GEF Rabex5 from endosomes while facilitating recruitment of the Rab7 GEF SAND-1/Mon1, promoting endosome maturation.

T-regulatory type 1 cells inherit a broad repertoire of epigenetic marks from T-follicular helper T-cells, offering new insights into the developmental biology of this subset.

The automated workflow significantly enhances the precision and scalability of cell cycle analysis, enabling high-throughput studies in both non-adherent and adherent cells for advanced cancer research and drug development.

Characterization of an abundant clonogenic and multipotent population of immature neuroblasts, at the transition between transient-amplifying progenitor (TAP) neuroblasts and migratory neuroblasts, reversibly engaged in neuronal differentiation.

Cells adapt to extracellular hypertonicities using regulatory volume increase (RVI), and TNFR1-mediated NFkB activation is indispensable for RVI, but the increased cytoplasmic macromolecular crowding can inhibit TNFR1 signaling and prevent RVI at severe hypertonicities.

A novel 2D-to-3D human brain organoid protocol reveals the pivotal role of FGF8 signaling in driving regional patterning and cellular diversity, while also modulating genes crucial for both normal and pathological neural development.