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    1. Ecology
    2. Evolutionary Biology

    Old age variably impacts chimpanzee engagement and efficiency in stone tool use

    Elliot Howard-Spink, Tetsuro Matsuzawa ... Dora Biro
    Long-term standardized data collection on wild western chimpanzees reveals late-life changes in stone tool use, and the extent of these changes varies between individuals.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention

    Alisa Sukhina, Clemence Queriault ... Will Bailis
    Dysregulated myelopoiesis is identified as a driver of nutritionally acquired immunodeficiency that persists after refeeding and nutritional recovery, indicating exposure to food scarcity may be an immunologic risk factor.
    1. Cell Biology
    2. Developmental Biology

    Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes

    Dylan A Valencia, Angela N Koeberlein ... Margot E Quinlan
    Complementary biochemical and cell-biological approaches reveal that formin FHOD3-mediated actin elongation, rather than nucleation, is critical for maintaining cardiomyocyte sarcomeres.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms

    Sean A Ridout, Priyathama Vellanki, Ilya Nemenman
    A simple mathematical model, incorporating reversible deactivation of β-cells, can potentially explain the rapid onset and remission of a diabetes subtype, ketosis-prone diabetes.
    1. Neuroscience

    Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability

    Joshua D Garcia, Chenyu Wang ... Kevin J Bender
    NaV1.2 and NaV1.6 have unique functional roles in neocortical pyramidal cells, regulating dendritic and axonal excitability, respectively.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Molecular Landscape of the Mouse Adrenal Gland and Adjacent Adipose by Spatial Transcriptomics

    Małgorzata Blatkiewicz, Szymon Hryhorowicz ... Marcin Rucinski
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    Unreliable homeostatic action potential broadening in cultured dissociated neurons

    Andreas Ritzau-Jost, Salil Rajayer ... Stefan Hallermann
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Microbiology and Infectious Disease

    Secreted small RNAs of Naegleria fowleri are biomarkers for diagnosis of primary amoebic meningoencephalitis

    A Cassiopeia Russell, Joseph Dainis ... Dennis E Kyle
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Cell Biology
    2. Neuroscience

    PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

    Shiyi Wang, Ryan Baumert ... Cagla Eroglu
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    A cortical–hippocampal communication undergoes rebalancing after new learning

    Arron F Hall, Dong V Wang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
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