Browse our latest research

Page 165 of 1,742
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Molecular dynamics simulations illuminate the role of sequence context in the ELF3-PrD-based temperature sensing mechanism in plants

    Richard J Lindsay, Rafael Giordano Viegas ... Sonya M Hanson
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Patch-walking, a coordinated multi-pipette patch clamp for efficiently finding synaptic connections

    Mighten C Yip, Mercedes M Gonzalez ... Craig R Forest
    Patch-walking is a novel automated patch clamp approach for finding synaptic connections in brain tissue, yielding 80–92% more probed connections than traditional approaches.
    1. Neuroscience

    Electrophysiological dynamics of salience, default mode, and frontoparietal networks during episodic memory formation and recall revealed through multi-experiment iEEG replication

    Anup Das, Vinod Menon
    Human intracranial electroencephalography recordings across 177 participants and four diverse episodic memory experiments demonstrate how the anterior insula node of the salience network orchestrates dynamics of large-scale brain networks.
    1. Physics of Living Systems

    A scale-invariant log-normal droplet size distribution below the critical concentration for protein phase separation

    Tommaso Amico, Samuel Toluwanimi Dada ... Amos Maritan
    The scaling invariance of the droplet size distribution as a universal aspect of protein phase separation is reported, providing a quantitative approach to determinate the critical concentration for this process.
    1. Neuroscience

    Brain state and cortical layer-specific mechanisms underlying perception at threshold

    Mitchell P Morton, Sachira Denagamage ... Anirvan S Nandy
    States of elevated arousal and stable retinal images allow enhanced processing of threshold stimuli in the laminar microcircuits of area V4.
    1. Structural Biology and Molecular Biophysics

    Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ

    Jinsai Shang, Douglas J Kojetin
    Commonly used covalent PPARγ inhibitors weaken, but do not block, binding of other ligands via an allosteric mechanism where ligands clash with a covalent ligand-induced transcriptionally repressive structural conformation.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Introduction of cytosine-5 DNA methylation sensitizes cells to oxidative damage

    Joanna Krwawicz, Caroline J Sheeba ... Peter Sarkies
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Structure of human PIEZO1 and its slow inactivating channelopathy mutants

    Yuanyue Shan, Xinyi Guo ... Duanqing Pei
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Neuroscience

    Integration of overlapping sequences emerges with consolidation through medial prefrontal cortex neural ensembles and hippocampal–cortical connectivity

    Alexa Tompary, Lila Davachi
    Changes in cortical neural ensembles and heightened coupling between the hippocampus and cortex enable the eventual behavioral integration of memories with overlapping sequential information.