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Page 210 of 1,762
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    The interplay between biomolecular assembly and phase separation

    Giacomo Bartolucci, Ivar S Haugerud ... Christoph A Weber
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Computational and Systems Biology

    De novo-designed minibinders expand the synthetic biology sensing repertoire

    Zara Y Weinberg, Sarah S Soliman ... Hana El-Samad
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Cell Biology
    2. Neuroscience

    Neurons enhance blood–brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion

    Lu Yang, Zijin Lin ... Li Liu
    The established triple co-culture blood-–brain barrier (BBB) model could be used for predicting drugs’ BBB permeability, and co-culture with neurons and astrocytes enhanced brain endothelial cells’ integrity by secreting GDNF, which upregulated claudin-5 and VE-cadherin expression.
    1. Neuroscience

    Transformation of valence signaling in a mouse striatopallidal circuit

    Donghyung Lee, Nathan Lau ... Cory M Root
    The representation of odor transforms from high dimensional, population level encoding of valence and identity in the OT, to a low dimensional representation of valence in the VP.
    1. Cell Biology
    2. Neuroscience

    Rab11 suppresses neuronal stress signaling by localizing dual leucine zipper kinase to axon terminals for protein turnover

    Seung Mi Kim, Yaw Quagraine ... Jung Hwan Kim
    Coupling between subcellular localization and protein turnover of a neuronal stress kinase, DLK, and its role in neuronal stress responses in Drosophila.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis

    Hoang Thanh Hai, Le Thanh Hoang Nhat ... Nguyen Thuy Thuong Thuong
    An unbiased transcriptomic analysis enhances understanding of inflammatory pathways and genes linked to TBM pathogenesis and mortality, identifying potential markers for poor prognosis or therapeutic targets.
    1. Medicine

    The zinc transporter Slc30a1 (ZnT1) in macrophages plays a protective role against attenuated Salmonella

    Pinanong Na-Phatthalung, Shumin Sun ... Fudi Wang
    Zinc transporter Slc30a1 mediates antibacterial defense in macrophages.
    1. Structural Biology and Molecular Biophysics

    Elucidating ATP’s role as solubilizer of biomolecular aggregate

    Susmita Sarkar, Saurabh Gupta ... Jagannath Mondal
    ATP prevents condensation of aggregation-prone intrinsically disordered protein by modulating its conformation.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Intraspecific predator interference promotes biodiversity in ecosystems

    Ju Kang, Shijie Zhang ... Xin Wang
    Intraspecific predator interference enables a wide range of consumer species to coexist with a limited variety of resources, explaining the paradox of the plankton and species diversity patterns across ecosystems.
    1. Neuroscience

    PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation

    Typhaine Comyn, Thomas Preat ... Pierre-Yves Plaçais
    In neurons of the Drosophila brain’s memory center, PKCδ relays a post-learning dopamine signal to mitochondria, boosting their metabolic activity and thereby unlocking long-term memory formation.