Browse our latest research

Page 214 of 1,761
    1. Ecology

    Range geographies, not functional traits, explain convergent range and phenology shifts under climate change

    Catherine Sirois-Delisle, Susan CC Gordon, Jeremy T Kerr
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

    MeiQing Han, Xia Wang ... Fan Yang
    Gut microbiota dysbiosis increased Nos2 expression through the 'gut–lung axis', and altered intracellular antimicrobial and anti-inflammatory environment by abnormal NO, ROS, and Defb1, thereby promoting Mycobacteria colonization in mouse lungs.
    Version of Record
    Research Article
    • Important
    • Compelling
    • Incomplete
    1. Neuroscience

    Hypothalamic representation of the imminence of predator threat detected by the vomeronasal organ in mice

    Quynh Anh Thi Nguyen, Andrea Rocha ... Sachiko Haga-Yamanaka
    A molecular genetics study reveals an accessory olfactory-to-hypothalamic circuit in mice that optimizes defensive behaviors according to the imminence of predator threats.
    1. Cell Biology

    Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress

    Li Sun, Xuejin Chen ... Quan-wen Jin
    Inhibitory effect on the activation of anaphase-promoting complex/cyclosome (APC/C) by MAPK Pmk1.
    1. Neuroscience

    PVN-mPFC OT projections modulate pup-directed pup care or attacking in virgin mandarin voles

    Lu Li, Yin Li ... Fadao Tai
    Activation of oxytocin (OT) neurons in the paraventricular nucleus or their projections to medial prefrontal cortex or periphery OT administration facilitated pup caring and inhibited infanticide, while inhibitions of these neurons and projections promoted infanticide.
    1. Computational and Systems Biology
    2. Neuroscience

    Supercomputer framework for reverse engineering firing patterns of neuron populations to identify their synaptic inputs

    Matthieu K Chardon, Y Curtis Wang ... Charles J Heckman
    Estimating the organization of supraspinal input to motoneurons in humans is not currently possible, but a promising reverse engineering technique has been developed using large-scale supercomputing and computational neuroscience.
    1. Microbiology and Infectious Disease

    A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin

    Maneesh Kumar Singh, Victoria Ann Bonnell ... Celia RS Garcia
    Multi-omic analyses reveal that the chromatin-associated microrchidia protein, MORC (PF3D7_1468100), at the blood stage of the human malaria parasite, Plasmodium falciparum, interacts with a range of nuclear proteins.
    1. Neuroscience

    Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction

    Adlin Abramian, Rein I Hoogstraaten ... Matthijs Verhage
    Live imaging at single-vesicle resolution reveals rabphilin-3A as the first identified negative regulator of neuropeptide release in mammalian neurons.
    Version of Record
    Research Article
    • Important
    • Convincing
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    HIV integrase compacts viral DNA into biphasic condensates

    Pauline J Kolbeck, Marjolein de Jager ... Willem Vanderlinden
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    LAPTM4B Alleviates Pulmonary Fibrosis by Enhancing NEDD4L-Mediated TGF-β Signaling Suppression

    Kai Xu, Xiaoyue Pan ... Guoying Yu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid