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Page 266 of 1,751
    1. Cell Biology
    2. Genetics and Genomics

    Temporally controlled nervous system-to-gut signaling bidirectionally regulates longevity in C. elegans

    Lingxiu Xu, Chengxuan Han ... Jianfeng Liu
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Developmental Biology

    Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination

    Ruonan Zhao, Emma L Moore ... Paul A Trainor
    Epithelial to mesenchymal transition (EMT) is a continuous process, in which the transition or intermediate states can be molecularly and spatially defined, shedding new light on development and disease EMT.
    1. Cancer Biology

    A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma

    Haley R Noonan, Alexandra M Thornock ... Leonard I Zon
    An in vivo reporter of TGFb signaling in zebrafish reveals that melanoma cells undergoing chronic TGFb signaling up-regulate extracellular matrix genes, down-regulate IFN, and are preferentially phagocytosed by macrophages compared to non-TGFb responsive melanoma cells.
    1. Neuroscience

    Distance and grid-like codes support the navigation of abstract social space in the human brain

    Zilu Liang, Simeng Wu ... Chao Liu
    New data provides partial evidence that abstract social knowledge adopts a similar encoding scheme as spatial cognitive maps in the human brain.
    1. Neuroscience
    2. Evolutionary Biology

    Investments in photoreceptors compete with investments in optics to determine eye design

    Francisco JH Heras, Simon B Laughlin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Martinize2 and Vermouth: Unified Framework for Topology Generation

    PC Kroon, F Grunewald ... SJ Marrink
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    • Incomplete
    1. Neuroscience

    Three-photon excited fluorescence microscopy enables imaging of blood flow, neural structure and inflammatory response deep into mouse spinal cord in vivo

    Yu-Ting Cheng, Kawasi M. Lett ... Chris B. Schaffer
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Nonlinear feedback modulation contributes to the optimization of flexible decision-making

    Xuanyu Wu, Yang Zhou
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology

    Loss of ninein interferes with osteoclast formation and causes premature ossification

    Thierry Gilbert, Camille Gorlt ... Andreas Merdes
    It is shown that the absence of the centrosome protein ninein provokes premature ossification during mouse development, due to a defect in the fusion of precursor cells into syncytial osteoclasts.
    1. Genetics and Genomics

    Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington’s disease

    Doo Eun Choi, Jun Wan Shin ... Jong-Min Lee
    Uninterrupted CAG repeat length determines onset age in Huntington's disease, and therefore, base editing strategies to generate CAA interruption offer new therapeutic opportunities as they diminish the disease-causing mutation.
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