A key finding is that MCAK binds to the proximal region of GTP cap where GDP‧Pi-tubulins accumulate, in addition to curved protofilaments at the distalmost tip.
The review proposes a novel mechanistic distinction between first- and second-order traveling waves that subserves a same canonical computation by ordering neuronal processing to impose a computational syntax.
The path of potassium through an ATP-dependent membrane pump is elucidated with a high-resolution structure within a lipid bilayer together with mutational analysis at key points along this pathway.
Rahul K Suryawanshi, Priyadarshini Jaishankar ... James S Fraser
The development of new small molecules demonstrates how pharmacologic inhibition of the coronavirus macrodomain restores innate immunity, leading to reduced viral replication and improved outcomes in severe infection.
