TAK1 plays a negative role in esophageal squamous cancer cell metastasis, which depends on the TAK1-induced phosphorylation of PLCE1 at S1060 and subsequent inhibition of PIP2 hydrolysis.
Simply crushed zizyphi spinosi semen not only ameliorates Aβ, tau, and α-synuclein pathology in dementia model mice, but also rejuvenates brain function by suppressing cellular senescence in normal aged mice.
β-CTF of APP, not Aβ, induces synaptic loss in a cell-autonomous manner, revealing APP misregulation may contribute to the pathogenesis of Alzheimer's disease via an Aβ-independent mechanism.
Germline V-gene usage can be inferred from cryoEM reconstructions of antigen-antibody complexes to guide de novo antibody sequencing of complex mixtures by mass spectrometry.
SFSWAP was identified in a genetic screen to negatively regulate splicing of OGT and other mRNAs primarily by regulating intron retention and exon skipping.
Benjamin Le Gac, Marine Tournissac ... Bruno Cauli
Increased neuronal activity of cortical pyramidal cells can paradoxically reduce cerebral blood flow via vasoconstriction mediated by glutamate and lipid messengers.
The thickness of the periplasmic region is reduced in strains of pneumococcus that are deleted in genes responsible for the incorporation of teichoic acid in the cell envelope.
