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    1. Neuroscience

    Single-cell RNAseq analysis of spinal locomotor circuitry in larval zebrafish

    Jimmy J Kelly, Hua Wen, Paul Brehm
    Single-cell transcriptomics of larval zebrafish spinal cord reveal ion channels and exocytotic machinery that enhance transmitter release in neuronal types shown to mediate high-speed swimming and escape behavior.
    1. Chromosomes and Gene Expression

    What AlphaFold tells us about cohesin’s retention on and release from chromosomes

    Kim A Nasmyth, Byung-Gil Lee ... Jan Löwe
    Structural predictions using AlphaFold suggest a mechanism by which Wapl mediates cohesin's dissociation from chromatin, a process whose downregulation is essential for VDJ recombination and diverse protocadherin gene expression.
    1. Neuroscience

    Judging the difficulty of perceptual decisions

    Anne Löffler, Ariel Zylberberg ... Daniel M Wolpert
    Deciding which of two perceptual decisions is more difficult involves sequential sampling processes that terminate when the difference in accumulated evidence for each decision exceeds a threshold.
    1. Neuroscience

    Selective transduction and photoinhibition of pre-Bötzinger complex neurons that project to the facial nucleus in rats affects nasofacial activity

    Mariana R Melo, Alexander D Wykes ... Andrew M Allen
    The pre-Bötzinger complex, known as the kernel for the breathing generation, consists of separate subpopulations of neurons that project to specific nuclei to coordinate respiratory rhythmicity with different physiological behaviors, such as nasofacial activity.
    1. Cell Biology

    Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability

    Ke Lu, Ming Zhang ... Di Chen
    Cyclin D1 protein stability is regulated by ubiquitin-proteasome mechanism mediated by multiple E3 ligases, including newly identified Keap1, DDB2, and WSB2.
    1. Developmental Biology

    The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)–phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline during zebrafish heart tube formation

    Rabina Shrestha, Tess McCann ... Joshua Bloomekatz
    Research on heart tube assembly using zebrafish reveals a pivotal role for intrinsic Pdgfra–PI3K signaling in steering the movement of the myocardium and polarizing myocardial cell protrusions.
    1. Neuroscience

    Conscious processing of global and local auditory irregularities causes differentiated heartbeat-evoked responses

    Diego Candia-Rivera, Federico Raimondo ... Jacobo D Sitt
    Brain-heart interactions under the processing of auditory irregularities could help to distinguish whether a patient is in a vegetative state or in a minimally conscious state.
    1. Cancer Biology
    2. Medicine

    Tissue-derived exosome proteomics identifies promising diagnostic biomarkers for esophageal cancer

    Dingyu Rao, Hua Lu ... Zhixian Tang
    Exosomal CD54 can be used as an effective biomarker for esophageal squamous cell carcinoma and CD54 promotes the proliferation and migration of tumor cells in vitro.
    1. Neuroscience

    Combined transcranial magnetic stimulation and electroencephalography reveals alterations in cortical excitability during pain

    Nahian Shahmat Chowdhury, Alan KI Chiang ... Siobhan M Schabrun
    Combined TMS-EEG can be used to further elucidate the mechanisms for pain perception and to discover biomarkers for the development of chronic pain.
    1. Ecology
    2. Evolutionary Biology

    miR-252 targeting temperature receptor CcTRPM to mediate the transition from summer-form to winter-form of Cacopsylla chinensis

    Songdou Zhang, Jianying Li ... Xiaoxia Liu
    The first comprehensive study on the regulation mechanism of miR-252 and temperature receptor CcTRPM on insect seasonal polyphenism will also conducive to designing a new method for pest control.