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Page 425 of 1,751
    1. Cell Biology

    Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation

    Eline Lemerle, Jeanne Lainé ... Stéphane Vassilopoulos
    Caveolae and Bin1 form tubulation platforms.
    1. Cell Biology

    Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions

    Florian Geisler, Sanne Remmelzwaal ... Rudolf E Leube
    Aberrant cytoskeletal intermediate filament networks in the C. elegans intestine are associated with hyperphosphorylated intermediate filament proteins and impact not only intestinal cell structure but have also detrimental consequences for organismal well-being.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Alternative paths to immune activation: the role of costimulatory risk genes for polygenic inflammatory disease in T helper cells

    Alexandru-Ioan Voda, Kristina Correa ... Luke Jostins-Dean
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Plant Biology

    Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?

    Yaron Caspi, Chrysoula K Pantazopoulou ... Kaisa Kajala
    Recent findings about the possible intercellular signalling role of glutamate, GABA, and melatonin might help to establish hypotheses concerning the evolutionary factors that caused intercellular organisms to use specific molecules in intercellular signalling.
    1. Epidemiology and Global Health
    2. Neuroscience

    Impact of social isolation on grey matter structure and cognitive functions: A population-based longitudinal neuroimaging study

    Laurenz Lammer, Frauke Beyer ... A Veronica Witte
    Analyses of longitudinal neuroimaging data highlight the importance of social contact for brain health.
    1. Genetics and Genomics

    Allele-specific gene-editing approach for vision loss restoration in RHO-associated retinitis pigmentosa

    Xiaozhen Liu, Jing Qiao ... Liping Yang
    The allele-specific gene-editing drug is expected to make RHO-T17M-associated retinitis pigmentosa therapy a reality.
    1. Cancer Biology

    MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

    Changyu Zhu, Yadira M Soto-Feliciano ... Scott W Lowe
    Epigenetic regulator MLL3 is mutated and lost in human hepatocellular carcinoma due to its ability to activate a well-defined tumor suppressor and cell death in transformed cells.
    1. Cell Biology

    The Uso1 globular head interacts with SNAREs to maintain viability even in the absence of the coiled-coil domain

    Ignacio Bravo-Plaza, Victor G Tagua ... Miguel A Peñalva
    Uso1 critically regulating traffic in the ER/Golgi interface is a coiled-coil protein traditionally regarded as a tether, but a forward genetic screen revealed that its essential role appears to involve its ability to interact with SNAREs.
    1. Cell Biology

    Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis

    Emmeline Marchal-Duval, Méline Homps-Legrand ... Arnaud A Mailleux
    Inhibition of a single fibroblast-associated transcription factor, namely Paired-related Homeobox Protein 1 (PRRX1), is sufficient to dampen lung fibrogenesis.
    1. Biochemistry and Chemical Biology

    Ribozyme activity modulates the physical properties of RNA–peptide coacervates

    Kristian Kyle Le Vay, Elia Salibi ... Hannes Mutschler
    The physical properties of model coacervate protocells are modulated by the activity of an RNA ligase ribozyme, which confers resistance to growth, surface wetting, and material exchange, establishing a link between RNA sequence and protocell phenotype.