Browse our latest research

Page 464 of 1,838
    1. Neuroscience

    Bayesian analysis of phase data in EEG and MEG

    Sydney Dimmock, Cian O'Donnell, Conor Houghton
    A Bayesian model of phase angles illustrates a novel approach to the analysis of phase coherence in frequency-tagged experiments.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural foundation for the role of enterococcal PrgB in conjugation, biofilm formation, and virulence

    Wei-Sheng Sun, Lena Lassinantti ... Ronnie P-A Berntsson
    The enterococcal adhesin PrgB consists of four immunoglobulin-like domains that support the proper function of its polymer adhesin domain.
    1. Developmental Biology

    C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy

    Hui Zhang, Chan Li ... Baohua Ma
    In vitro and in vivo data show that C-natriuretic peptide is significant for increasing mitochondrial bioenergetics by cAMP-PKA pathway and improving cytoplasmic and nuclear maturation of maternally aged oocyte.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission

    Elliott L Paine, Jack J Skalicky ... Wesley I Sundquist
    Biochemical, structural, imaging, and functional studies reveal how the ESCRT-III protein IST1 recruits the CAPN7 cysteine protease to midbodies, where its proteolytic activity is required for efficient abscission and NoCut checkpoint arrest.
    1. Cancer Biology
    2. Genetics and Genomics

    Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells

    Ann-Kathrin Herzfeldt, Marta Puig Gamez ... Lee Kim Swee
    Loss of membrane-bound ICAM-1, overexpression of soluble ICAM-1 or ILKAP activity in tumor cells induce resistance to antigen-specific cytotoxic T-cell-mediated killing independently from regulating antigen presentation, PD-L1 expression, IFN-γ, or TNF-α responsiveness.
    1. Neuroscience
    2. Physics of Living Systems

    Mechanical vibration patterns elicit behavioral transitions and habituation in crawling Drosophila larvae

    Alexander Berne, Tom Zhang ... Mason Klein
    Habituation to mechanical vibration of crawling Drosophila larvae exhibits distinct time constants that characterize desensitization, re-sensitization, and further adaptation to repeated stimulus patterns.
    1. Cell Biology

    β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

    Carole Daly, Akim Abdul Guseinov ... Bianca Plouffe
    The vasopressin type 2 receptor promotes dual Gαs and Gαq/11 signaling at early endosomes in β-arrestin-dependent and -independent manners.
    1. Computational and Systems Biology

    Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

    Xiaoxu Li, Jean-David Morel ... Johan Auwerx
    A strategy combining large mouse and human genetic data sheds light on dietary and genetic drivers of gut inflammation.
    1. Cancer Biology
    2. Computational and Systems Biology

    High-content microscopy reveals a morphological signature of bortezomib resistance

    Megan E Kelley, Adi Y Berman ... Gregory P Way
    Morphological profiling of untreated HCT116 cells using Cell Painting reveals a signature of bortezomib resistance, providing a proof-of-concept for the unbiased analysis of drug resistance.
    1. Cell Biology

    PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis

    Shuxian Li, Lingbing Li ... Xietong Wang
    Airborne PM2.5 exposure triggers oxidative stress and mitochondrial apoptosis in placental trophoblast cells via the KLF9/CYP1A1 transcriptional axis, ultimately leading to adverse pregnancy outcomes.