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The nuclear membrane protein SUN1 stabilizes endothelial cell-cell junctions far from the nucleus via regulation of microtubule dynamics and Rho GEF-H1 signaling, revealing long-range cellular communication important for vascular development and function.

Crystal structures of taxane-tubulin complexes allow the understanding of the interaction of paclitaxel (Taxol) with its cellular target in atomic detail and assess the structural determinants for binding.

The cryo-electron microscopy structures of an LRRC8C chimera with native channel properties reveal the diverse oligomeric assembly and suggest that lipids may play a role in gating in volume-regulated anion channels.

Structural mass spectrometry reveals conformational changes in emerging SARS-CoV-2 spike protein variants that correlate with increased viral fitness.

A novel lncRNA marks the Irf8 downstream enhancer that is crucial for differentiation of plasmacytoid dendritic cells (pDC) and classical dendritic cells type 1 (cDC1) and confers feedback inhibition of Irf8 transcription.

TANGO2 emerges as a key regulator of fatty acid metabolism by likely affecting acyl-CoA production and utilization.

Transferred mitochondria do not always regulate cell behavior by simply restoring mitochondrial function, but rather, transferred mitochondria are dysfunctional, initiating downstream signaling and proliferation in response to reactive oxygen species.

Acute lymphoblastic and myeloblastic leukemias activate lymphotoxin beta receptor in mesenchymal stem cells in the bone marrow to turn off interleukin-7 production and lymphopoiesis and gain competitive advantage.

The ABO and RhD blood groups are associated with disease-wide susceptibility differences.

The important oncogene KRasG13C can be targeted by covalently binding nucleotide-analogues, resulting in a locked protein that can no longer induce oncogenic signaling.