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Cell-surface heparan sulfate clusters, not the generally assumed ACE2, mediate SARS-CoV-2 attachment and endocytic entry, fundamentally revising the viral entry paradigm and establishing heparan sulfate as a primary therapeutic target.

Mechanical interactions at the interface of mutant and wild-type cell populations govern tissue-specific responses to oncogenic transformation in epithelia, causing mutants to be extruded, spatially restrained, or undergo persistent expansion.

Estrogen receptor 1 (ESR1)-positive neurons in the pontine micturition center govern detrusor–sphincter coordination via three distinct spinal projections, representing a therapeutic target for detrusor–sphincter dyssynergia and associated voiding dysfunction.

Parallelized, cloud-compatible pipelines reduce spike sorting of large-scale neural recordings from weeks to hours, and enable systematic benchmarking of algorithms on hybrid data.

Tracking luminescent reporter light intensity is a fast, easy way to quantify population decline at high concentrations and tends to be a better proxy for biomass than for cell number.

Age-specific templates improve the quality of functional alignment using hyperalignment algorithms, and the improvement is consistent across age groups, validation analyses, and datasets.

Cooperation between individual virions of human cytomegalovirus at infecting cells leads to nonlinear scaling of cell infection probability with virion concentration.

Modeling the metabolic microenvironment of pancreatic tumors leads to the identification of polyunsaturated fatty acid metabolism as a vulnerability of pancreatic cancer.