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Treatment with a JAK inhibitor normalizes multiple biomarkers of autoinflammation and provides therapeutic benefit for diverse immune skin conditions in individuals with Down syndrome.

Downregulation of Sema4A in keratinocytes induces psoriatic non-lesional features, with its signaling cascades potentially triggering psoriasis and serving as targets for treatment and prevention.

In Drosophila, the planar cell polarity protein Flamingo is required by winners to maintain their status during cell competition in multiple models as they compete to occupy excessive territory within wildtype tissues.

Metabolic abnormalities in hepatocytes cause the alteration of transcriptional profile and function of immune cells in the tissue microenvironment.

Alterations of auditory prediction patterns were robustly found in tinnitus using two independent samples.

Rationalized selection of responsive TCR clones by single-cell analysis to aid in the generation of novel TCR transgenic animals.