Browse our latest research

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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase

    Omar Herrera-Asmat, Alexander B Tong ... Carlos Bustamante
    Optical tweezers are used to gain mechanistic insight in the mechanism of inhibition of three distinct compounds being developed as antibiotics against Mycobacterium tuberculosis.
    1. Developmental Biology
    2. Cancer Biology

    Tumors mimic the niche to inhibit neighboring stem cell differentiation

    Yang Zhang, Yuejia Wang ... Shaowei Zhao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression

    Endogenous Real Time Imaging Reveals Dynamic Chromosomal Mobility During Ligand-Mediated Transcriptional Burst Events

    Susan Wang, Thomas Suter ... Michael G Rosenfeld
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Biochemistry and Chemical Biology

    Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice

    Yuna Izumi-Mishima, Rie Tsutsumi ... Hiroshi Sakaue
    Muscle-derived branched-chain amino acids support thermogenesis in brown adipose tissue, thereby helping maintain body temperature during impaired muscle function or physiological stress.
    1. Neuroscience

    Tonotopy is not preserved in a descending stage of auditory cortex

    Miaoqing Gu, Shanshan Liang ... Xiaowei Chen
    Cortical feedback to the thalamus lacks the precise spatial organization seen in ascending pathways.
    1. Evolutionary Biology

    The holocephalan ratfish endoskeleton shares trabecular and areolar mineralization patterns, but not tesserae, with elasmobranchs little skate and catshark

    Oghenevwogaga Joseph Atake, Fidji Berio ... B Frank Eames
    Novel and published data confirm that cartilaginous fishes (chondrichthyans) from many different clades share interesting skeletal features that are similar to bone, but some 'classic' chondrichthyan features are not shared.
    1. Medicine
    2. Neuroscience

    Functional Muscle Networks as Biomarkers of Post-Stroke Motor Impairment and Therapeutic Responsiveness

    David O’Reilly, Giorgia Pregnolato ... Giacomo Severini
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Single-cell transcriptome sequencing for opening the blood-brain barrier through specific mode electroacupuncture stimulation

    Congcong Ma, Zhaoxing Jia ... Xianming Lin
    Single-cell transcriptome sequencing results of rats intervened with specific mode electroacupuncture (an emerging method for opening the blood-brain barrier).
    1. Genetics and Genomics

    Rewiring the bone marrow: Evolution and the transcriptional architecture of trained immunity

    Sarah J Sun, Raúl Aguirre-Gamboa, Luis B Barreiro
    Hematopoietic reprogramming reflects the selective and evolutionarily conserved engagement of transcription factor networks that encode innate immune memory in long-lived stem cells.
    1. Neuroscience

    The Crunchometer: A Low-Cost, Open-Source Acoustic Analysis of Feeding Microstructure

    Elvi Gil-Lievana, Benjamin Arroyo ... Ranier Gutierrez
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    • Incomplete