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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins

    Shinichi Kawaguchi, Xin Xu ... Toshie Kai
    AlphaFold2-based large-scale screening reveals novel protein interactions, accelerating functional studies of piRNA pathway proteins and expanding bioinformatic-experimental integration.
    1. Neuroscience

    Auditory cortex learns to discriminate audiovisual cues through selective multisensory enhancement

    Song Chang, Beilin Zheng ... Liping Yu
    Experience-driven plasticity in auditory cortex neurons establishes cross-modal associations, enabling enhanced discrimination of multisensory cues through specialized integrative strategies.
    1. Immunology and Inflammation

    MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles

    Linsey Peters, Leonida Rakateli ... Emiel van der Vorst
    Lipid nanoparticles containing microRNA-26-mimics can reduce MASH in mice, providing a novel therapeutic approach.
    1. Cancer Biology
    2. Cell Biology

    Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction

    Xiangning Bu, Nathanael Ashby ... Inhee Chung
    Cell crowding drives a pro-invasive mechanotransduction pathway in high-grade DCIS, inducing TRPV4 inhibition, calcium and cell volume reduction, and increased invasion, with compensatory plasma-membrane TRPV4 relocation indicating pathway activation.
    1. Computational and Systems Biology
    2. Neuroscience

    Neural population dynamics underlying evidence accumulation in multiple rat brain regions

    Brian DePasquale, Carlos D Brody, Jonathan W Pillow
    A computational framework for combining neural and behavioral data to infer latent dynamics underlying decision-making reveals distinct accumulation dynamics in different brain regions in the rat.
    1. Neuroscience

    Semantic representations in the visual cortex of blind and sighted humans

    Małgorzata Paczyńska, Marta Urbaniak ... Łukasz Bola
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    No effect of additional education on long-term brain structure – a preregistered natural experiment in thousands of individuals

    Nicholas Judd, Rogier Kievit
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Auditory stimuli extend the temporal window of visual integration by modulating alpha-band oscillations

    Mengting Xu, Biao Han ... Lu Shen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    Switching perspective: Comparing ground-level and bird’s-eye views for bumblebees navigating dense environments

    Annkathrin Sonntag, Odile Sauzet ... Olivier Bertrand
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Neuroscience

    Stimulus dependencies—rather than next-word prediction—can explain pre-onset brain encoding during natural listening

    Inés Schönmann, Jakub Szewczyk ... Micha Heilbron
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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