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    1. Cancer Biology

    Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies

    Sander Frank, Thomas Persse ... Peter S Nelson
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Perceptual glimpses are locally accumulated and globally maintained at distinct processing levels

    Elisabeth Parés-Pujolràs, Anna C Geuzebroek ... Simon P Kelly
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    A GCN1-independent activator of the kinase GCN2

    JiaYi Zhu, Giulia Emanuelli ... Stefan J Marciniak
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Spatial frequency adaptation modulates population receptive field sizes

    Ecem Altan, Catherine A Morgan ... D Samuel Schwarzkopf
    Modulations in population receptive field size induced by spatial frequency adaptation reveal a direct link between spatial tuning in the visual cortex and spatial frequency selectivity of neuronal populations.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity

    Eric Greene, Richard Muniz ... James S Fraser
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Evolutionary Biology

    Heterozygote advantage cannot explain MHC diversity, but MHC diversity can explain heterozygote advantage

    Joshua L Cherry
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology
    2. Neuroscience

    Segment-specific axon guidance by Wnt/Fz signaling diversifies motor commands in Drosophila larvae

    Suguru Takagi, Shiina Takano ... Akinao Nose
    Rewiring the command neurons in the tactile circuit is sufficient to change the behavioral strategy of a whole animal, implying a 'plug-and-play' flexibility in sensorimotor circuits.
    1. Cell Biology
    2. Neuroscience

    The effects of 17α-estradiol treatment on endocrine system revealed by single-nucleus transcriptomic sequencing of hypothalamus

    Lei Li, Guanghao Wu ... Yinchuan Li
    Long-term 17α-estradiol modulates aged male hypothalamic function via HPG axis and energy metabolism, mitigating aging-related neuronal changes.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    The molecular infrastructure of glutamatergic synapses in the mammalian forebrain

    Julia Peukes, Charlie Lovatt ... René AW Frank
    CryoCLEM-guided cryoET of Psd95-GFP knockin mouse tissue and ultra-fresh synaptonerosomes indicate that the postsynaptic density is a not a conserved feature of glutamatergic synapses in the mouse brain.
    1. Genetics and Genomics
    2. Neuroscience

    Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

    Tom Bonnifet, Sandra Sinnassamy ... Julia Fuchs
    LINE-1-encoded ORF1p is widely expressed in neurons, increases with age, and engages neuron-specific protein partners, revealing a dynamic role for retrotransposons in brain physiology and aging.
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