Morgan P Kain, Eloise B Skinner ... Erin A Mordecai
The role host and vector species play in pathogen transmission cycles is best quantified by integrating species' physiological and ecological competence.
Genetic integration of human protein abundance variation and COVID-19 susceptibility identifies proteins with potential causal roles in antiviral responses, coagulation, cytokine activation, and direct receptor interactions with SARS-CoV-2.
Brendan Cornwell, Katrina Armstrong ... Stephen R Palumbi
Bleaching-resistant corals are widespread across Palau and concentrated in warmer regions, but this trait is associated with decreased growth which could lead to reduced fitness if it is the only priority of conservation efforts.
Urszula Nowicka, Piotr Chroscicki ... Agnieszka Chacinska
Defective mitochondrial protein import results in protein aggregation and a specific chaperone response in the cytosol, causatively linking mitochondrial function and cellular protein homeostasis disturbances observed in neurodegeneration.
Clara Bouyx, Marion Schiavone ... Jean Marie François
The role of amyloid-β-aggregation sequence and of the various domains in the physiological function of the FLO11-encoded adhesin in the yeast Saccharomyces cerevisiae are disclosed in this report.
Ariana R Andrei, Samantha Debes ... Valentin Dragoi
Focal optogenetic inactivation of cortex induces complex changes in neural responses outside the targeted area that can influence behavioral performance.
Lawrence Lubyayi, Harriet Mpairwe ... Alison M Elliott
In a Ugandan birth cohort, early childhood infection-exposure, notably to malaria, helminths, and diarrhoea, is associated with lower prevalence of atopy and allergy-related diseases in later childhood.
In vivo dopamine neuron imaging-based neuroprotective small molecule screen in larval zebrafish and mechanistic investigation using conditional CRISPR knockout and cell-type-specific RNA-seq analysis, coupled with cross-species analyses including human clinical data interrogation, uncover potential disease-modifying therapeutics for Parkinson's disease (PD).
