The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.
Mohammed Kaplan, Georges Chreifi ... Grant J Jensen
Electron cryo-tomography reveals that bacteria can form structurally-diverse outer membrane extensions with various protein complexes associated with them.
The crystal structure of human WIPI2 bound to the ATG16L1 WIPI2-interacting region, combined with in vitro reconstitution and cellular autophagy assays, shows how the LC3 lipidation machinery is recruited in autophagy initiation.
James P Bohnslav, Nivanthika K Wimalasena ... Christopher D Harvey
DeepEthogram automatically classifies animal behavior videos into researcher-defined behaviors of interest, saving researcher time and enabling more detailed downstream analysis of behavior.
David M Garcia, Edgar A Campbell ... Daniel F Jarosz
In its capacity to switch into a heritable, prionogenic form, a conserved RNA-modifying enzyme epigenetically alters fundamental growth, aging, and protein synthesis properties of eukaryotic cells.
An integrated empirical paradigm tracing immune strategies, underlying mechanisms and infection outcomes across reservoir host-pathogen systems, their specific ecological contexts, life-history features, and coevolutionary dynamics can reveal the actual patterns and processes underlying spillover in the wild.
Genetic and functional manipulations uncover urocortin-3-expressing neurons in the perifornical area of the hypothalamus as a dedicated circuit component for the expression of infant-directed neglect and aggression in mice.
Regina Rillo-Bohn, Renzo Adilardi ... Abby F Dernburg
Investigation of meiosis in the nematode Pristionchus pacificus has illuminated evolutionary variation in this essential aspect of reproduction and established a new model for future study.
Michael A Barnett, Geoffrey K Aguirre, David Brainard
A quantitative forward model captures fMRI responses to chromatic stimuli in human primary visual cortex and quantifies how chromatic sensitivity changes with eccentricity.
