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    1. Biochemistry and Chemical Biology

    Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

    Knut H Lauritzen, Maria Belland Olsen ... Arne Yndestad
    Transgenic mice and cell models provide evidence of a pathophysiological mechanism that connects mtDNA damage to cardiac dysfunction via reduced NAD+ levels and loss of mitochondrial function and communication.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A covariation analysis reveals elements of selectivity in quorum sensing systems

    Samantha Wellington Miranda, Qian Cong ... E Peter Greenberg
    The extension of covariation analyses to proteins that coevolve but do not physically interact enabled identification of selectivity residues in quorum sensing proteins, providing insight into the evolution of signaling systems.
    1. Developmental Biology

    An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment

    Zhaoyang Liu, Amro A Hussien ... Ryan S Gray
    The regulation of the biomechanical properties of tendons/ligaments is essential for the maintenance of spine alignment in the mouse.
    1. Cell Biology

    Different translation dynamics of β- and γ-actin regulates cell migration

    Pavan Vedula, Satoshi Kurosaka ... Anna Kashina
    β- and γ-cytoplasmic actins have different translation rates in cells and exert different nucleotide coding sequence-dependent effects on cell migration.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Homo-oligomerization of the human adenosine A2A receptor is driven by the intrinsically disordered C-terminus

    Khanh Dinh Quoc Nguyen, Michael Vigers ... Songi Han
    The C-terminus of A2A receptor drives oligomer formation via an intricate network of disulfide bonds, hydrogen bonds, electrostatic interactions, and hydrophobic interactions, all of which are enhanced by depletion interactions.
    1. Neuroscience

    Tracking the relation between gist and item memory over the course of long-term memory consolidation

    Tima Zeng, Alexa Tompary ... Sharon L Thompson-Schill
    Human learners’ memory for generalities across individual items biased memory for these items after 1 month.
    1. Neuroscience

    Sequence structure organizes items in varied latent states of working memory neural network

    Qiaoli Huang, Huihui Zhang, Huan Luo
    Items at different positions of a sequence are maintained in distinct latent states of working memory system and are reactivated in reverse order over time, which is further related to recency effect in memory behavior.
    1. Neuroscience

    Interpreting wide-band neural activity using convolutional neural networks

    Markus Frey, Sander Tanni ... Caswell Barry
    A novel deep-learning framework shows how to interpret and decode raw neural recordings, avoiding the need for strong prior hypotheses, revealing a novel representation of head direction.
    1. Neuroscience

    An oscillating computational model can track pseudo-rhythmic speech by using linguistic predictions

    Sanne ten Oever, Andrea E Martin
    An oscillating computational model combined with a predictive internal linguistic model can track naturally timed speech in which pseudo-rhythmicity is related to the predictability of words within their sentence context.
    1. Ecology

    Rapid spread of a densovirus in a major crop pest following wide-scale adoption of Bt-cotton in China

    Yutao Xiao, Wenjing Li ... Kongming Wu
    Exposure to Bacillus thuringiensis (Bt) selects for beneficial interactions between the target insect pest (Helicoverpa armigera) and its symbiotic densovirus that enhances its performance on Bt-crops under field conditions.