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The flow of neural activity across the cortico-cerebellar loop enables mice to reach for objects with skill and precision.

Autoinhibition allows synaptic endocytic actin regulators to pre-deploy to synaptic membranes at high concentrations and constrains actin assembly to productive events.

Genetic and biochemical approaches uncover a novel mode of regulation of the alarmone synthetase RelA through a functional and direct interaction with the small subunit of the nitrite reductase NirD.

Temporally delayed linear modelling provides a domain-general linear framework for sequence detection and statistical testing, and is able to detect replays in both human neuroimaging and animal electrophysiology.

RNA polymerase recruits the PcrA DNA helicase via a conserved interaction motif in order to remove R-loops and prevent conflicts with replication.

The ribbon synapses of zebrafish UV-cone photoreceptors preferentially transmit transient or sustained components in light-stimuli depending on their location in the eye.

Ferroptotic stress enhances the accumulation of damage-associated inflammatory proximal tubular cell state, thereby promoting maladaptive renal repair and the AKI-to-CKD transition.

Prodrug antibiotics can be designed that are serum-stable but readily cleaved inside bacterial pathogens.

Alpha oscillations represent an intermediate stage of evidence accumulation that is influenced by self-regulation in value-based decision making.

A newly discovered substrate of Pak1 kinase reveals novel mechanisms that control cell shape through regulated assembly of ribonucleoprotein granules.