Universal gut microbial relationships in the gut microbiome of wild baboons
- Duke University, United States
- University of Groningen, Netherlands
- University of Pittsburgh, United States
- University of Notre Dame, United States
- University of British Columbia, Canada
- University of Chicago, United States
- University of California, San Diego, United States
Abstract
Ecological relationships between bacteria mediate the services that gut microbiomes provide to their hosts. Knowing the overall direction and strength of these relationships is essential to learn how ecology scales up to affect microbiome assembly, dynamics, and host health. However, whether bacterial relationships are generalizable across hosts or personalized to individual hosts is debated. Several eco-evolutionary processes could personalize microbiome community ecology, but the few studies that have tested this idea find that bacterial interactions are largely consistent (i.e., 'universal') across hosts. Here we apply a robust, multinomial logistic-normal modeling framework to extensive time series data (5,534 samples from 56 wild baboons over 13 years) to infer thousands of correlations in bacterial abundance in individual hosts and test the degree to which bacterial abundance correlations are 'universal'. We also compare these patterns to two human data sets. We find that, in baboons, most bacterial correlations are weak, negative, and universal across hosts, such that shared correlation patterns dominate over host-specific correlations by almost 2-fold. Further, taxon pairs that had inconsistent correlation signs (either positive or negative) in different hosts always had weak correlations within hosts. From the host perspective, host pairs with the most similar bacterial correlation patterns also had similar microbiome taxonomic compositions and tended to be genetic relatives. Compared to humans, universality in baboons was similar to that in human infants, and stronger than one data set from human adults. Bacterial families that showed universal correlations in human infants also tended to show universal correlations in baboons. Together, our work contributes new tools for analyzing the universality of bacterial associations across hosts, with implications for microbiome personalization, community assembly and stability, and for designing microbiome interventions to improve host health.
Data availability
16S rRNA gene sequences are available on EBI-ENA (project 590 ERP119849) and Qiita (study 12949). Analyzed data and code are available on GitHub at: https://github.com/kimberlyroche/rulesoflife
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DIABIMMUNE three country cohortThe NCBI BioProject ID for these data is PRJNA290380.
Article and author information
Author details
Elizabeth A Archie
Funding
National Science Foundation (DEB1840223)
- Jack A Gilbert
- Elizabeth A Archie
National Institute on Aging (R01AG071684)
- Elizabeth A Archie
National Institute on Aging (R21AG055777)
- Ran Blekhman
- Elizabeth A Archie
National Institute on Aging (R01AG053330)
- Elizabeth A Archie
National Institute of General Medical Sciences (R35GM128716)
- Ran Blekhman
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Dario Riccardo Valenzano, Leibniz Institute on Aging, Germany
Publication history
- Received: September 1, 2022
- Accepted: May 8, 2023
- Accepted Manuscript published: May 9, 2023 (version 1)
Copyright
© 2023, Roche et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Universal gut microbial relationships in the gut microbiome of wild baboons
eLife 12:e83152.
https://doi.org/10.7554/eLife.83152
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