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    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Alzheimer’s Disease: The two shapes of the Tau protein

    Jeffery W Kelly
    Tau proteins can convert from an inert shape to a misfolded shape that seeds the growth of fibers that contribute to the pathology of Alzheimer's disease.
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    1. Cell Biology

    Cell Division: Shining light on spindle positioning

    Andrea Serra-Marques, Sophie Dumont
    Optogenetic approaches are leading to a better understanding of the forces that determine the plane of cell division.
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    1. Evolutionary Biology

    Genome Evolution: We are not so special

    Zachary R Lewis, Casey W Dunn
    New sequence data from choanoflagellates improves our understanding of the genetic changes that occurred along the branch of the evolutionary tree that gave rise to animals.
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    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Metabolism: Division of labor in bacteria

    Alma Dal Co et al.
    The emergence of subpopulations that perform distinct metabolic roles has been observed in populations of genetically identical bacteria.
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Bone-Targeting Drugs: From vesicle to cytosol

    Michael J Rogers, Marcia A Munoz
    Drugs called bisphosphonates are used to treat a range of bone diseases, but how do they reach the enzymes that are their target?
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    1. Neuroscience

    Descending neurons: Disentangling the strings that organize behavior

    Matthieu Louis, Julie H Simpson
    The neurons that connect the brain and ventral nerve cord in fruit flies have been mapped in unprecedented detail.
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    1. Biochemistry and Chemical Biology

    Convergent Evolution: Shaping the import system of mitochondria

    Kostas Tokatlidis
    Evidence is accumulating that unrelated species have independently evolved the same way of importing proteins in their mitochondria.
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    1. Biochemistry and Chemical Biology

    In Vitro Evolution: Rethinking the tools of the RNA world

    Antony Crisp, Thomas Carell
    An artificially evolved ribozyme can catalyse the synthesis of RNA by using trinucleotide triphosphates as building blocks.
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    1. Structural Biology and Molecular Biophysics

    Electrophysiology: Leading the charge

    Andrew JR Plested
    A simple label-free method uses the electrical properties of cells to detect how ligands bind to membrane proteins.
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    1. Developmental Biology
    2. Immunology and Inflammation

    Chemokines: The cell sets the tone

    Jonna Alanko, Michael Sixt
    In zebrafish larvae, it is the cell type that determines how the cell responds to a chemokine signal.
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