Browse our Insights

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    1. Computational and Systems Biology
    2. Genetics and Genomics

    Wnt Signaling: Exploring the origins of a signaling pathway

    Balaji Santhanam
    The 19 Wnt proteins found in humans are part of a larger superfamily of proteins that are also found in Archaea and Bacteria.
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    1. Developmental Biology

    Morphogenesis: Regulating closure of the neural tube in humans

    Leon Qarawani, Jacob H Hanna
    An organoid-based screening platform that allows one-gene-at-a-time knockdown across a whole tissue has been used to identify the genes that regulate closure of the neural tube in humans.
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    1. Neuroscience

    Numerical Cognition: Is ‘number sense’ a sense?

    Toshiya Matsushima
    Experiments on domestic chicks shed light on the links between brain lateralization and the left-to-right mental number line.
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    1. Neuroscience

    Dorsal Vagal Complex: A cell atlas to guide research into appetite control

    Greta Lommi, Thomas A Lutz
    An atlas of all the cell types in the dorsal vagal complex of rodents will help neuroscientists seeking to understand appetite and researchers working to design better drugs for the treatment of obesity and related disorders.
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    1. Neuroscience

    Connectomes: The wiring diagram of an entire animal

    Alex M Winsor, Paul S Katz
    A digital atlas of every cell in a developing marine worm reveals how networks across the body coordinate sensing and movement, and provides insights into the evolution of the nervous system.
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    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Homologous Recombination: Snapshot of an intermediate structure

    Akira Shinohara
    Cryogenic electron microscopy has been used to determine the detailed structure of an intermediate state called a “D-loop” that forms when strands of DNA are exchanged during homologous recombination.
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    1. Evolutionary Biology

    Microfossils: Mimicking early life-forms in the lab

    Maarten Lubbers, Dennis Claessen
    Studying the growth of bacteria without cell walls in an artificial environment can shed new light on the proliferation of primitive life-forms billions of years ago.
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    1. Cell Biology

    Membrane Biology: Nothing can replace polyunsaturated lipids

    Sofia Rodriguez-Gallardo, Takeshi Harayama
    Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
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    1. Neuroscience

    Behavioral Neuroscience: The consequences of stress on the brain and fear

    Nicole C Ferrara, Sydney Trask
    A region of the brain called the paraventricular thalamus mediates the impact of stress on unlearned fear responses, but is not involved in learned fear behavior.
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    1. Developmental Biology
    2. Neuroscience

    Ribbon Synapses: Taking the tube to the basal pole of hair cells

    Satish R Ghimire, Thomas M Coate
    A stable microtubule network and kinesin motors facilitate the formation of presynaptic ribbons in sensory hair cells in the zebrafish lateral line.
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