TRACC (Transcriptional Readout Activated by Cell-cell Contacts) is an engineered molecular tool that detects and records cell-cell contacts in mammalian systems.
Deep mutagenesis experiments demonstrate that while cancer-causing mutations in Ras selectively alter regulatory interactions with GTPase-activating proteins, Ras is also activated by many mutations that decrease protein stability.
Computational modelling predicts spatial segregation of different types of nuclear transport receptors in assemblies of nuclear pore proteins, lending support to the idea of separate transport pathways in the nuclear pore complex as a way to enhance transport efficiency.
Effective navigation of odor plumes in the wild requires that animals sense multiple temporal aspects of odor signals, which are encoded naturally by neurons in the fly olfactory circuit.
Daniel W Belsky, Avshalom Caspi ... Terrie E Moffitt
DunedinPACE is a novel DNA methylation biomarker of the pace of biological aging for intervention trials and natural experiment studies investigating how the rate of aging may be changed by behavioral or drug therapy, or by environmental modification.
Genetic analysis and biochemical approaches reveal that chemorefractory properties are reversed by inhibiting mucin secretion, thus providing a means to curb the growth and spread of colorectal cancer.
Matthew W Parker, Jonchee A Kao ... Michael R Botchan
The intrinsically disordered regions (IDRs) of metazoan DNA replication licensing factors phase separate through synergistic electrostatic DNA-IDR and hydrophobic inter-IDR interactions.
Pupil diameter cannot accurately predict spiking activity in the locus coeruleus on a moment-by-moment basis, and exhibited large fluctuations to identical stimulation in the LC.
