Dnajb6 is identified as a novel sick sinus syndrome causative gene that exhibits a unique expression pattern within a subpopulation of sinus node pacemaker cells.
Coarse-grained modeling of mammalian kinetochore-fiber shapes generated under microneedle manipulation reveals the need for lateral anchorage 1-3 μm from the kinetochore to robustly preserve their orientation in the spindle center, promoting mechanical integrity in the dynamic spindle.
Substrate recognition by a receptor protein tyrosine phosphatase is mediated by binding to its pseudophosphatase domain via a short helix that is >100 amino acids distant from the target phosphosite, uncovering principles of phosphatase substrate recognition and potential scaffolding functions.
Tanja Fuchsberger, Claudia Clopath ... Ole Paulsen
Neuronal reactivation during dopamine modulation induces input-specific LTP at previously primed hippocampal synapses, suggesting a possible solution to the credit assignment problem and a mechanism for memory linking.
Dylan J Meyer, Carlos Manlio Díaz-García ... Gary Yellen
Neuronal glycolysis to restore energy consumed by ion movements is activated by engagement of the Na+/K+ pump, either directly by Na+ influx or indirectly, when Ca2+ influx is converted to Na+ accumulation by Na+/Ca2+ exchange.
Inactivation of SURF4 leads to impaired secretion of PCSK9 and apolipoproteins resulting in low plasma cholesterol without detrimental consequences to the liver.
Edmundo G Vides, Ayan Adhikari ... Suzanne R Pfeffer
Parkinson’s disease-associated LRRK2 kinase is recruited to membranes by its Rab GTPase substrates, and LRRK2 is both retained on membranes and further activated there by cooperative interaction with the phosphorylated Rab proteins that it generates.
David S Jacobs, Madeleine C Allen ... Bita Moghaddam
A novel approach to studying anxiety reveals that learned anxiety and diazepam treatment have unique roles on prefrontal cortex and ventral tegmental area activity.
