Browse our Research Advances

Page 12 of 45
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    A dual-target herbicidal inhibitor of lysine biosynthesis

    Emily RR Mackie, Andrew S Barrow ... Tatiana P Soares da Costa
    The first recently discovered inhibitors of lysine biosynthesis with in planta activity have a dual-target mode of action, which provides proof-of-concept for the development of multi-target ‘resistance-resistant’ herbicides with a novel mode of action.
    1. Cell Biology
    2. Developmental Biology

    DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells

    Jason KH Lai, Pearlyn JY Toh ... Timothy E Saunders
    Substrate rigidity modulates genomic stress in the epidermal basal cells of the developing zebrafish embryo and Yap1 and Wwtr1 are required for its survival.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

    Morgane Boone, Lan Wang ... Michael Schoof
    Genetically induced conformational modulation of eIF2B activates the Integrated Stress Response by impairing nucleotide exchange.
    1. Neuroscience

    Human visual gamma for color stimuli

    Benjamin J Stauch, Alina Peter ... Pascal Fries
    Colored surfaces induce gamma oscillations in human early visual cortex that are equally strong for red and green colors when L-M cone contrast is controlled for.
    1. Cell Biology
    2. Physics of Living Systems

    Single-cell monitoring of dry mass and dry mass density reveals exocytosis of cellular dry contents in mitosis

    Teemu P Miettinen, Kevin S Ly ... Scott R Manalis
    A high-resolution approach for monitoring dry mass and the density of that dry mass on a single-cell level is developed and used to reveal that mammalian cells can lose components in mitosis due to lysosomal exocytosis.
    1. Neuroscience

    The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice

    Han Zhang, Natalia A Shevtsova ... Ilya A Rybak
    The role of genetically identified V3 interneurons with ascending propriospinal projections in the spinal locomotor circuitry and their contribution to the limb coordination and speed-dependent gait expression during locomotion were investigated using a combination of experimental studies and computational modeling.
    1. Neuroscience

    Short-term plasticity in the human visual thalamus

    Jan W Kurzawski, Claudia Lunghi ... Paola Binda
    Short-term monocular deprivation effects are widespread in the visual cortex and extend subcortically to the ventral pulvinar, while sparing the dorsal pulvinar and the lateral geniculate nucleus.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular determinants of complexin clamping and activation function

    Manindra Bera, Sathish Ramakrishnan ... James E Rothman
    Complexin, in conjunction with Synaptotagmin, clamps the SNARE-assembly process under resting conditions and promote vesicle fusion in response to calcium signal.
    1. Epidemiology and Global Health

    Inference of the SARS-CoV-2 generation time using UK household data

    William S Hart, Sam Abbott ... Robin N Thompson
    Updated estimates of the generation time of SARS-CoV-2 infections indicate that the generation time has become shorter.
    1. Cell Biology

    Cortical microtubule pulling forces contribute to the union of the parental genomes in the Caenorhabditis elegans zygote

    Griselda Velez-Aguilera, Batool Ossareh-Nazari ... Lionel Pintard
    Cortical microtubule pulling forces influence nuclear envelope breakdown, while nuclear envelope remodeling, particularly lamina depolymerization, impacts mitotic spindle length during mitosis.