Browse our Research Advances

Page 17 of 51
    1. Developmental Biology

    Transgenic quails reveal dynamic TCF/β-catenin signaling during avian embryonic development

    Hila Barzilai-Tutsch, Valerie Morin ... Olivier Serralbo
    A novel avian transgenic line allows studying the function of Wnt signaling during embryonic development.
    1. Neuroscience

    Flexible and efficient simulation-based inference for models of decision-making

    Jan Boelts, Jan-Matthis Lueckmann ... Jakob H Macke
    A new machine learning method makes it possible to efficiently identify the parameters of cognitive models using Bayesian inference, even when only model simulations are available.
    1. Neuroscience

    Exogenous capture accounts for fundamental differences between pro- and antisaccade performance

    Allison T Goldstein, Terrence R Stanford, Emilio Salinas
    The detection of a salient stimulus triggers a stereotypical oculomotor response, an impulse to look toward it, whose timing and strength are largely independent of behavioral significance and top-down control.
    1. Developmental Biology
    2. Evolutionary Biology

    Gene expression phylogenies and ancestral transcriptome reconstruction resolves major transitions in the origins of pregnancy

    Katelyn Mika, Camilla M Whittington ... Vincent J Lynch
    Mammals evolved an invasive placenta early in the origins of pregnancy.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Conserved structural elements specialize ATAD1 as a membrane protein extraction machine

    Lan Wang, Hannah Toutkoushian ... Peter Walter
    A mitochondrial membrane-bound protein ATAD1 uses conserved structural elements to remove mislocalized membrane proteins from the outer mitochondrial membrane, achieving proper cell organization.
    1. Neuroscience

    Predictions and experimental tests of a new biophysical model of the mammalian respiratory oscillator

    Ryan S Phillips, Hidehiko Koizumi ... Jeffrey C Smith
    The predictive power of a computational model advances understanding of the neuronal and circuit biophysical mechanisms that generate the respiratory rhythm and neural activity patterns in the mammalian brainstem.
    1. Genetics and Genomics

    An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination

    Oguz Kanca, Jonathan Zirin ... Hugo J Bellen
    New construct designs and gene targeting strategies from the Gene Disruption Project allow efficient tagging of almost all Drosophila genes.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    A dual-target herbicidal inhibitor of lysine biosynthesis

    Emily RR Mackie, Andrew S Barrow ... Tatiana P Soares da Costa
    The first recently discovered inhibitors of lysine biosynthesis with in planta activity have a dual-target mode of action, which provides proof-of-concept for the development of multi-target ‘resistance-resistant’ herbicides with a novel mode of action.
    1. Cell Biology
    2. Developmental Biology

    DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells

    Jason KH Lai, Pearlyn JY Toh ... Timothy E Saunders
    Substrate rigidity modulates genomic stress in the epidermal basal cells of the developing zebrafish embryo and Yap1 and Wwtr1 are required for its survival.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

    Morgane Boone, Lan Wang ... Michael Schoof
    Genetically induced conformational modulation of eIF2B activates the Integrated Stress Response by impairing nucleotide exchange.