Emir E Avilés-Pagán, Masatoshi Hara, Terry L Orr-Weaver
The Drosophila PNG kinase controls mRNA translation at the oocyte-to-embryo transition, and its GNU activating subunit is shown here to bind translational repressors and be a component of RNP granules.
Descending interneurons maintain synaptic connectivity and behavioral function despite pruning during metamorphosis, showing that synaptic specificity is established twice at different life stages.
Computational modeling and a cell cycle-reporting axolotl reveal how spinal cord regeneration can be achieved by a signal that propagates 828 μm from the injury site during the first 85 hours post-amputation.
Persistent, non-random sensorimotor connectivity reveals the capacity of intrinsic spinal networks to purposefully replay and modify learned patterns of neural transmission during unconsciousness.
Philip Jean-Richard-dit-Bressel, Jessica C Lee ... Gavan P McNally
Punishment insensitive individuals are not more impulsive or anxious, they dislike aversive outcomes and predictors of these outcomes, but are simply less likely to learn their control over them.
Substrate-induced structural changes in GtACR1 provide new insight into the chemical mechanism of natural light-gated anion conductance and facilitate its optimization for photoinhibition of neuron firing in optogenetics.
Colin M Cleary, Brenda M Milla ... Daniel K Mulkey
Cellular and chemogenetic approaches identify a novel mode of chemotransduction involving regulation of basal breathing by CO2/H+-dependent disinhibition.
BEST1 autosomal dominant loss-of-function mutations surprisingly behave in a dominant-negative manner, whereas gain-of-function mutations exhibit a strong dominant effect that necessitates CRISPR/Cas9-mediated suppression of the endogenous mutant allele in gene therapy.
Alvaro Gonzalez Rajal, Kamila A Marzec ... Andrew Burgess
Platinum chemotherapy resistance is a complex process involving multiple signalling pathways and a novel, non-genetic, cell cycle-dependent mechanism that promotes tumour regrowth and highlights potential complications for combination therapies in human lung adenocarcinoma.
