Browse our Research Advances

Genetic analysis of Hippo pathway kinases in a close unicellular relative of animals suggests an ancestral role of this ancient pathway in regulating cytoskeletal dynamics and density of multicellular aggregates.

Neural fluctuations in multiple areas along the visual cortical hierarchy could allow the brain to represent distinct co-occurring visual stimuli.

The gain of transposable elements in yeast hybrids does not scale with genetic divergence levels and is most impacted by structural variations and multiple aspects of individual hybrid genetic backgrounds.

A massively parallel reporter assay, mSTARR-seq, reveals widespread DNA methylation-environment interactions across the genome, prioritizing CpG sites identified in epigenome-wide association studies that may be most relevant to biological embedding.

Region of Attainable Redaction analysis allows scientists to estimate the potential impacts of redaction in biomedical science, helping to uncover potentially spurious or non-robust results.

Hippocampome.org v1.0, a foundational classification system of hippocampal neuron types, has evolved into 2.0, which recenters the focus on new functionality to build real-scale, biologically detailed, data-driven computational simulations.

Quantitative analysis of cell dynamics over a range of timescales reveals that core PCP is not required to organize large-scale tissue flows but does affect short timescale mechanics.

Improved cell-type-specific genetic drivers for the study of learning and memory and other complex behaviors in Drosophila are provided and validated.

An enhanced bioinformatic pipeline to quantify Plasmodium falciparum core gene and polymorphic var gene expression revealed changes occurring during early culture adaptation of parasites from naturally infected individuals.

Microbial macroecological patterns under coarse-graining are captured by a null model of ecology, a result which was leveraged to successfully predict the relationship between fine and coarse-grained diversity.