Browse our Research Advances

Page 23 of 47
    1. Biochemistry and Chemical Biology

    Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

    Deepti Karandur, Moitrayee Bhattacharyya ... John Kuriyan
    Activation and autophosphorylation of CaMKII releases the regulatory segment, which can then bind to and destabilize the hub assembly by trapping large fluctuations in the hub architecture.
    1. Cell Biology
    2. Developmental Biology

    Live imaging of hair bundle polarity acquisition demonstrates a critical timeline for transcription factor Emx2

    Yosuke Tona, Doris K Wu
    Acquisition of hair bundle orientation in sensory hair cells is only sensitive to Emx2 during a critical time window.
    1. Developmental Biology
    2. Neuroscience

    Establishment and maintenance of motor neuron identity via temporal modularity in terminal selector function

    Yinan Li, Anthony Osuma ... Paschalis Kratsios
    The terminal selector-type transcription factor UNC-3/Ebf partially modifies the suite of its target genes at different life stages to establish and maintain the identity of C. elegans motor neurons.
    1. Computational and Systems Biology
    2. Neuroscience

    New insights on the modeling of the molecular mechanisms underlying neural maps alignment in the midbrain

    Elise Laura Savier, James Dunbar ... Michael Reber
    A dominant sensory map provides positional information through correlated activity and transposed molecular cues to guide secondary sensory projections for alignment and organization.
    1. Neuroscience

    Vascular control of the CO2/H+-dependent drive to breathe

    Colin M Cleary, Thiago S Moreira ... Daniel K Mulkey
    Understanding how loss of CO2/H+ vascular reactivity affects respiratory control may facilitate development of treatments for breathing problems in this population.
    1. Neuroscience

    Neural variability determines coding strategies for natural self-motion in macaque monkeys

    Isabelle Mackrous, Jérome Carriot ... Maurice J Chacron
    Whether central vestibular neurons implement faithful stimulus encoding for the vestibulo-occular reflex or optimized coding via temporal whitening for other vestibular functions is determined by neural variability.
    1. Cell Biology
    2. Developmental Biology

    Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts

    Amrutha Kizhedathu, Rose Sebastian Kunnappallil ... Arjun Guha
    Wnts can act synergistically to affect G2 arrest via transcriptional upregulation of a Checkpoint Kinase in the absence of any detectable DNA damage.
    1. Neuroscience

    Post-tetanic potentiation lowers the energy barrier for synaptic vesicle fusion independently of Synaptotagmin-1

    Vincent Huson, Marieke Meijer ... Lennart Niels Cornelisse
    Modulation of the energy barrier for membrane fusion is a common mechanism by which sensors in the synapse produce supralinear calcium dependence of vesicle release and short-term synaptic potentiation.
    1. Neuroscience
    2. Physics of Living Systems

    Efficient coding of natural scene statistics predicts discrimination thresholds for grayscale textures

    Tiberiu Tesileanu, Mary M Conte ... Vijay Balasubramanian
    An optimization principle allows natural-image data to predict human sensitivity to synthetic, un-natural textures with multiple gray levels.
    1. Neuroscience

    Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning

    Evan E Hart, Melissa J Sharpe ... Geoffrey Schoenbaum
    The orbitofrontal cortex is necessary for learning about value-neutral sensory associations to impact subsequent model-based behavior.