Browse our Research Advances

Page 50 of 51
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Single-fluorophore membrane transport activity sensors with dual-emission read-out

    Cindy Ast, Roberto De Michele ... Wolf B Frommer
    Building on previous work (De Michele et al., 2013), we report the development of dual-emission AmTrac sensors for in vivo analysis of transporter activity.
    1. Computational and Systems Biology

    Tuning the speed-accuracy trade-off to maximize reward rate in multisensory decision-making

    Jan Drugowitsch, Gregory C DeAngelis ... Alexandre Pouget
    Building on previous work (Drugowitsch et al., 2014), it is shown that decision-makers adjust their speed-accuracy trade-off flexibly from one moment to the next, based on evidence available from multiple sensory modalities, in order to nearly maximize their reward rate.
    1. Chromosomes and Gene Expression

    A simple method for generating high-resolution maps of genome-wide protein binding

    Peter J Skene, Steven Henikoff
    Building on previous work (Skene et al., 2014), we show that a new ChIP-seq protocol provides superior resolution and ease of use at low sequence depth of coverage for generating genome-wide maps of protein binding.
    1. Neuroscience

    Inter-individual stereotypy of the Platynereis larval visual connectome

    Nadine Randel, Réza Shahidi ... Gáspár Jékely
    Building on previous work (Randel et al., 2014), a comparison of the visual neuronal circuitry in two Platynereis larvae, made using serial electron microscopic reconstructions, reveals a high level of stereotypy in the synaptic connectivity.
    1. Neuroscience

    Thalamic theta phase alignment predicts human memory formation and anterior thalamic cross-frequency coupling

    Catherine M Sweeney-Reed, Tino Zaehle ... Alan Richardson-Klavehn
    Building on previous work (Sweeney-Reed et al., 2014), it is shown that the timing of the theta rhythm of the right anterior thalamic nucleus predicts human memory formation.
    1. Neuroscience

    Visual processing of informative multipoint correlations arises primarily in V2

    Yunguo Yu, Anita M Schmid, Jonathan D Victor
    Building on recent findings that central sensory processing allocates resources according to the informativeness of statistical features (Hermundstad et al., 2014), we identify visual area V2 as the site of the relevant computations for local image statistics, thus providing a common underpinning for diverse aspects of its neuronal selectivity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors

    Ayesa Syenina, Cyril J Jagaraj ... Ashley L St John
    Building on previous work (St John et al., 2013), we explain why secondary infection by dengue virus is associated with more severe vascular disease than primary infection.
    1. Cell Biology
    2. Developmental Biology

    Regions within a single epidermal cell of Drosophila can be planar polarised independently

    Miguel Rovira, Pedro Saavedra ... Peter A Lawrence
    Building on previous work (Saaverda et al., 2014), we show that the Dachsous/Fat system can polarise different parts of a single cell in opposite ways in the Drosophila larva.
    1. Cell Biology
    2. Neuroscience

    The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

    Carmela Sidrauski, Anna M McGeachy ... Peter Walter
    Building on previous work which showed that the small molecule ISRIB potently blocks the integrated stress response (Sidrauski et al., 2013), we report on ISRIB's remarkable specificity and fast action in vivo, underscoring its proposed direct effect on translation.
    1. Neuroscience

    A cortical disinhibitory circuit for enhancing adult plasticity

    Yu Fu, Megumi Kaneko ... Michael P Stryker
    Building on previous work (Kaneko and Stryker, 2014), we report that the specific population of inhibitory neurons that increases the responses of neurons in the visual cortex during locomotion will also, when activated or blocked artificially, dramatically alter adult cortical plasticity, revealing that the aerobic exercise of locomotion is not necessary.