Browse our Research Articles

Page 109 of 1,400
    1. Microbiology and Infectious Disease

    A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall

    Carlos A Ramirez Carbo, Olalekan G Faromiki, Beiyan Nan
    A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall and thus transmits proton motive force from the inner membrane to cell surface.
    1. Chromosomes and Gene Expression

    Transcription factor condensates, 3D clustering, and gene expression enhancement of the MET regulon

    James Lee, Leman Simpson ... Lu Bai
    The condensates of activator Met4 are associated with 3D clustering of the MET regulon and its enhanced expression.
    1. Medicine
    2. Neuroscience

    Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients

    Jörn Lötsch, Khayal Gasimli ... Marco Sisignano
    Sphinganine-1-phosphate (SA1P) is linked to paclitaxel-induced peripheral neuropathy, offering a potential target for reducing this severe side effect of paclitaxel treatment.
    1. Evolutionary Biology
    2. Neuroscience

    Neuro-evolutionary evidence for a universal fractal primate brain shape

    Yujiang Wang, Karoline Leiberg ... Bruno Mota
    Cortices from 11 primate species share the same archetypal fractal shape, indicating a universal mechanism for primate and mammalian cortical folding, and suggesting novel shape biomarkers for brains.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    An arms race between 5’ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish

    Shang Geng, Xing Lv ... Tianjun Xu
    5’ppp-RNA, a traditional ligand for RIG-I, can be recognized by MDA5 in species such as Miichthys miiuy and Gallus gallus that lack RIG-I.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Merging multi-omics with proteome integral solubility alteration unveils antibiotic mode of action

    Ritwik Maity, Xuepei Zhang ... Javier Sancho
    Like two peas in a pod but not exactly alike, similar molecules targeting the same bacterial protein behave differently, requiring systems biology and target deconvolution to gain better comprehension.
    1. Microbiology and Infectious Disease

    Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient

    Yuki Tatekoshi, Chunlei Chen ... Hossein Ardehali
    A calcium transient measurement system utilizing human induced pluripotent stem cell-derived cardiomyocytes reveals the detrimental impact of inflammatory cytokines on cardiomyocyte relaxation and displays the potential of drugs to reverse these defects.
    1. Physics of Living Systems

    Local volume concentration, packing domains, and scaling properties of chromatin

    Marcelo A Carignano, Martin Kroeger ... Igal Szleifer
    The Self Returning Excluded Volume model is the first heuristic, stochastic chromatin model that reproduce single cell and ensemble based experiments bridging nucleosome and chromosome scales.
    1. Neuroscience

    High-frequency terahertz stimulation alleviates neuropathic pain by inhibiting the pyramidal neuron activity in the anterior cingulate cortex of mice

    Wenyu Peng, Pan Wang ... Tao Chen
    For the first time, high-frequency terahertz stimulation is shown to effectively alleviate chronic pain symptoms in mice by regulating neuronal activity in the cortex.
    1. Neuroscience

    Task-dependent coarticulation of movement sequences

    Hari Teja Kalidindi, Frederic Crevecoeur
    Long-latency reflexes flexibly encode future goals during sequential reaching movements, reflecting the parallel and task-dependent processing of a sequence of goals in circuits that mediate fast feedback control.