Katherine A Senn, Karli A Lipinski ... Aaron A Hoskins
The Saccharomyces cerevisiae spliceosome component Fyv6 contributes to precursor messenger RNA splicing by promoting use of branch site distal 3' splice sites and interacting with key factors involved in exon ligation.
Tai-Ying Lee, Yves Weissenberger ... Johannes C Dahmen
Behavior is a major determinant of the activity of auditory midbrain neurons and can shape their responses independently of input from the auditory cortex.
Analyses of discovered cancer-driving nucleotides (CDNs) reveal their evolutionary, biochemical, and therapeutic characteristics that are often shared among multiple cancer types.
Arkadiy K Golov, Alexey A Gavrilov ... Sergey V Razin
A new genomic method called MChIP-C measures H3K4me3-associated chromatin interactions with extremely high resolution and sensitivity, detecting interactions in over 60% of functionally verified enhancer-promoter pairs.
The conformation of an isoleucine gate located along the TM6 segment on the intracellular side below the selectivity filter is a critical component leading to a non-conductive state in the C-type inactivation process of K+ channels.
Gerbils exhibit stable, family-specific vocal dialects over weeks, suggesting vocal communication may play a key role in representing kinship in natural social groups.
The important role of structural asymmetry in the functional lateralization of the same brain area provides a crucial insight into the neurobiological fundament for human brain's functional lateralization.
TIM23 core deficiency specifically impacts the oxidative phosphorylation and the mitochondrial ribosome complexes and, unexpectedly, leads to reduction of plasma membrane voltage-dependent potassium channels in neurons.
Attentional modulation is affected by target-distractor similarity, indicating tuning sharpening as the underlying mechanism for response enhancement during object-based attention.
Quan-Son Eric Le, Daniel Hereford ... Jonathan P Fadok
Associative and non-associative learning mechanisms summate to produce robust and complex conditioned behavior profiles, opening new avenues to in-depth investigations of defensive responses and threat evaluation.
