Browse our Research Articles

Page 20 of 1,442
    1. Physics of Living Systems

    Design principles of transcription factors with intrinsically disordered regions

    Wencheng Ji, Ori Hachmo ... Ariel Amir
    Intrinsically disordered regions in transcription factors enhance both target binding probability and search efficiency.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Telomeres control human telomerase (TERT) expression through non-telomeric TRF2

    Antara Sengupta, Soujanya Vinayagamurthy ... Shantanu Chowdhury
    Telomere length controls hTERT expression by modulating TRF2 distribution and PRC2-mediated repression, highlighting a self-regulatory mechanism in cancer.
    1. Neuroscience

    Sparse innervation and local heterogeneity in the vibrissal corticostriatal projection

    Kenza Amroune, Lorenzo Fontolan ... Ingrid Bureau
    Functional connectivity mapping reveals sparse, specific, and largely complementary cortical innervation of individual striatal medium spiny neurons within overlapping and loosely topographical projections from the barrel cortex.
    1. Neuroscience

    Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing

    Jiho Park, Grayson O Sipe ... Mriganka Sur
    Astrocytic GABA transporter 3 is essential for preserving the integrity of neuronal population dynamics in accurately encoding and representing sensory information.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Non-cognate immunity proteins provide broader defenses against interbacterial effectors in microbial communities

    Abigail Knecht, Denise Sirias ... Karine A Gibbs
    A biochemical and bioinformatics approach shows how T6SS immunity proteins bind to and neutralize a range of non-cognate effectors, which is critical for promoting bacterial fitness in mixed-strain environments.
    1. Neuroscience

    Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants

    Balázs István Tóth, Bahar Bazeli ... Thomas Voets
    Rapamycin, competing with other rapalogs, activates TRPM8 via directly binding to a novel binding site, which results in providing new insights into the mechanisms of TRPM8 activation.
    1. Evolutionary Biology

    Viral genome sequence datasets display pervasive evidence of strand-specific substitution biases that are best described using non-reversible nucleotide substitution models

    Rita Sianga-Mete, Penelope Hartnady ... Darren P Martin
    Non-reversible nucleotide substitution models best describe strand-specific nucleotide substitution biases of viral genomes.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites

    Steven P Maher, Malina A Bakowski ... Dennis E Kyle
    Drug repurposing screens reveal several epigenetic inhibitors as active against P. vivax hypnozoites demonstrating that epigenetic pathways play a central role in hypnozoite quiescence.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Adaptations in wing morphology rather than wingbeat kinematics enable flight in small hoverfly species

    Camille Le Roy, Nina Tervelde ... Florian T Muijres
    Small hoverflies compensate for size-related flight challenges through evolutionary changes in wing shape rather than altered wingbeat kinematics.
    1. Neuroscience

    Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells

    Mate Sumegi, Gaspar Olah ... Zoltan Nusser
    Two-photon Ca2+ imaging reveals that place fields of hippocampal place cells emerge with variable cellular mechanisms.