For the first time, mouse models reveal the metabolic dependency of photoreceptors on glutamine catabolism in vivo and further demonstrate the flexibility of photoreceptors to utilize fuel sources beyond glucose.
Jordina Rincon-Torroella, Marco Dal Molin ... Surojit Sur
Monocarboxylate transporter 1 overexpressed pancreatic cancers can be therapeutically targeted with ME3BP-7, a promising new agent with unique mode of action.
A computational study reveals that the kinetic models of Escherichia coli metabolism show strong responsiveness to perturbations and that it originates from cofactor dynamics and network sparsity.
Marius Seidenthal, Jasmina Redzovic ... Alexander Gottschalk
Caenorhabditis elegans FLWR-1/Flower is required for efficient synaptic vesicle recycling and does so through a functional and possibly direct physical interaction with the plasma membrane Ca2+ ATPase, MCA-3.
Philip Stavrides, Chris N Goulbourne ... Dun-Sheng Yang
ALP alterations in Q175 brains are late-onset, mild, existing at the later phases of the pathway, and stimulating autophagy at early disease progression enhances mHTT clearance to ameliorate HD pathology.
Yasuhiro Arimura, Hide A Konishi, Hironori Funabiki
A technique that enables single-particle cryo-EM analysis of targets on a magnetic bead and a particle curation method that helps structural classification of small particles has been developed.
The SUN1-ALLAN complex serves as a nuclear envelope–spanning tether that coordinates the segregation of a bipartite microtubule organising center (MTOC) during the unusual mitosis of Plasmodium.
It is proposed that place cells are arranged in a hexagonal grid for large surfaces devoid of landmarks, which produces grid cell receptive fields as an artifact of memory retrieval.
