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The crystal structure of Sld3CBD-Cdc45 shows its intermolecular interactions, and subsequent Sld3CBD-CMG model construction and binding assays enable a proposal for the mechanism of Cdc45 recruitment and Sld3 release.

The accessory genome of Mycobacterium tuberculosis is small, but differences in gene content are found both between and within lineages.

In Pseudomonas aeruginosa, the chemoreceptor cluster and flagellar motor colocalize at the same cell pole through FlhF anchoring, preventing cross-pathway signaling interference between chemotaxis and c-di-GMP regulation.

sIgM plays a role in viral neutralization across both primitive and modern vertebrates by following conserved principles in the development of specialized antiviral immunity.

SUL1 deletion extends lifespan via PKA-MSN2 pathways, underscoring nutrient signaling over sulfate transport in aging regulation.

CTCF binding promotes chromatin-nuclear speckle interactions and gene activation after DNA demethylation, yet its binding and looping patterns are unaffected by speckle depletion.

WRN and WRNP1 ATPases together with WRN 3’ to 5’ exonuclease raise the fidelity of intrinsically highly error-prone Y-family DNA polymerases such that they perform error-free translesion synthesis.

Coarse-grained models of cellular growth and high-throughput empirical genetic data support the Product neutrality function in which a double-mutant fitness is the product of single-mutant fitnesses.

The cryptic pocket is critical for one of the VP35 protein's functions and therefore is likely under selective pressure.

Differences among genetically identical individuals can be explained using expression levels of just a handful of genes, suggesting that environmental variation can be functionally analyzed.