Functional connectivity mapping reveals sparse, specific, and largely complementary cortical innervation of individual striatal medium spiny neurons within overlapping and loosely topographical projections from the barrel cortex.
Astrocytic GABA transporter 3 is essential for preserving the integrity of neuronal population dynamics in accurately encoding and representing sensory information.
A biochemical and bioinformatics approach shows how T6SS immunity proteins bind to and neutralize a range of non-cognate effectors, which is critical for promoting bacterial fitness in mixed-strain environments.
Rapamycin, competing with other rapalogs, activates TRPM8 via directly binding to a novel binding site, which results in providing new insights into the mechanisms of TRPM8 activation.
Steven P Maher, Malina A Bakowski ... Dennis E Kyle
Drug repurposing screens reveal several epigenetic inhibitors as active against P. vivax hypnozoites demonstrating that epigenetic pathways play a central role in hypnozoite quiescence.
Carmen Ruger-Herreros, Lucia Svoboda ... Bernd Bukau
The nuclear J-domain protein Apj1 controls the shut-off phase of the yeast heat shock response by displacing DNA-bound heat shock transcription factor Hsf1.