The SUN1-ALLAN complex serves as a nuclear envelope–spanning tether that coordinates the segregation of a bipartite microtubule organising center (MTOC) during the unusual mitosis of Plasmodium.
It is proposed that place cells are arranged in a hexagonal grid for large surfaces devoid of landmarks, which produces grid cell receptive fields as an artifact of memory retrieval.
Solution biophysics defines the influence of local dynamics and allosteric regulation on guide RNA binding affinity and DNA cleavage specificity in a thermophilic Cas9 from Geobacillus stearothermophilus.
Tendon regeneration is supported by human CD29+/CD56+ myogenic progenitors through tenogenic differentiation, representing a distinct stem cell population with therapeutic potential.
As a group, inattentionally blind participants can successfully report the location, color, and shape of stimuli they deny noticing, and exhibit a systematic bias to report not noticing.
The determination of GAGases structure facilitates the elucidation of the catalytic mechanism of PL35 family lyases and provides potential evidence for the hypothesis that GAG lyase evolved from alginate lyase.
Bird species with higher plasma glucose show comparatively lower albumin glycation, suggesting the evolution of glycation resistance mechanisms, and terrestrial carnivores present higher glycation than omnivores.
Viral-mediated Oct4 overexpression induces direct conversion of wildtype mammalian Müller glia to bipolar neurons, and this process is synergistically enhanced by loss of Notch signaling.
Rare individuals treated for congenital cataracts demonstrated shifts in the visual cortex’s excitatory/inhibitory balance even decades post-surgery, reflected by alterations in the neurotransmitter concentration ratio and aperiodic electroencephalogram activity.
Higher biosynthetic capacity of gut microbes in individuals diagnosed with noncommunicable diseases or taking antibiotics suggests that diversity loss and 'dysbiosis' result from microbiome restructuring in response to ecosystem disruption.
