Mycobacterium tuberculosis utilizes nucleomodulins to disrupt host inflammatory responses and lysosomal maturation, uncovering a novel strategy for immune evasion and intracellular survival.
Manuel Dominguez-Rodrigo, Enrique Baquedano ... Audax Mabulla
The discovery of the earliest direct evidence of systematic proboscidean butchery at Olduvai Gorge demonstrates that by 1.8 Ma early hominins had strategically integrated megafaunal exploitation into their subsistence systems.
Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.
Philip MM Ruppert, Aylin S Gueller ... Jan-Wilhelm Kornfeld
Transcriptomic profiling on liver and adipose depots reveals tissue-specific and beige-fat–convergent responses to methionine restriction and cold, providing a high-quality resource to guide combinatorial lifestyle interventions for metabolic disease research.
Self-related information automatically modulates early attentional selection into awareness through mechanisms distinct from physical salience, revealing an obligatory, individualized self-prioritization at the gateway to perception.
In statistical fine-mapping, signals stable across stratified subgroups can capture functionally important loci missed by covariate adjustment approaches, and prioritizing agreement between both approaches enhances functional variant discovery.
Anurag A Agrawal, Amy P Hastings, Paola Rubiano-Buitrago
Confirming coevolutionary theory, monarch butterfly caterpillars show impaired growth and toxin sequestration when feeding on realistic cardenolide mixtures from their milkweed host plants.
Antoine Bouyeure, Daniel Pacheco-Estefan ... Nikolai Axmacher
Fear updating relies on a flexible shift from generalized to item-specific, context-bound neural representations, revealing how the brain adapts to changing threat contingencies and why fear can return.
