Browse our Research Articles

Page 197 of 1,399
    1. Stem Cells and Regenerative Medicine

    An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis

    J Barney Bryson, Alexandra Kourgiantaki ... Linda Greensmith
    Stem-cell-based neural replacement, in combination with optogenetic stimulation, could represent a translationally viable therapeutic strategy to overcome atrophy and paralysis of targeted muscles in people living with amyotrophic lateral sclerosis.
    1. Neuroscience

    Dynamics and maintenance of categorical responses in primary auditory cortex during task engagement

    Rupesh K Chillale, Shihab Shamma ... Yves Boubenec
    Primary auditory cortex shows population-level correlates of sound categorization, with categorical patterns emerging during sound presentation and task engagement leading to asymmetrical representation of stimuli, indicating an early involvement in stimulus categorization.
    1. Neuroscience

    A generative model of electrophysiological brain responses to stimulation

    Diego Vidaurre
    Genephys is a generative model for dissecting the different aspects that compound our neural responses to perceptual stimulation, identifying which aspects remain stable and which ones vary across experimental repetitions.
    1. Neuroscience

    14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist intervention

    Qiuling Liu, Hua Yang ... Zhisheng Ji
    14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury in mice.
    1. Evolutionary Biology

    Evolution of the gene regulatory network of body axis by enhancer hijacking in amphioxus

    Chenggang Shi, Shuang Chen ... Guang Li
    The gene regulatory network of Nodal signaling, underpinning body axes patterning, was evolved specifically in cephalochordate lineage.
    1. Immunology and Inflammation

    Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS

    Daniel C Akuma, Kimberly A Wodzanowski ... Igor E Brodsky
    Caspase-11 catalytic activity and autoprocessing play key roles upstream rather than downstream of its assembly into higher-order inflammasome complexes in response to cytosolic bacterial lipopolysaccharide.
    1. Neuroscience

    Neuroendocrine gene expression coupling of interoceptive bacterial food cues to foraging behavior of C. elegans

    Sonia A Boor, Joshua D Meisel, Dennis H Kim
    Distinct interoceptive and gustatory bacterial food cues converge to control neuroendocrine gene expression in two neurons, which modulates and is correlated with internal states driving feeding versus foraging behavior.
    1. Neuroscience

    Serial attentional resource allocation during parallel feature value tracking

    Christian Merkel, Luise Burgmann ... Jens-Max Hopf
    The strong limitation of human subjects in tracking two color streams simultaneously as they independently traverse color space can be attributed to attention alternating slowly and sequentially between streams.
    1. Computational and Systems Biology
    2. Neuroscience

    Neuroimaging and behavioral evidence that violent video games exert no negative effect on human empathy for pain and emotional reactivity to violence

    Lukas Leopold Lengersdorff, Isabella C Wagner ... Claus Lamm
    After playing violent video games for 7 hr over the course of 2 weeks, human male participants show neither signs of decreased empathy for the pain of another person nor of decreased responsivity to violent images.
    1. Developmental Biology

    Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling

    Steven A Cincotta, Nainoa Richardson ... Diana J Laird
    Although developing oocytes and sperm of mice both harbor the glucocorticoid receptor, fetal oocytes are resistant to differing levels of gluocorcorticoid stress hormones, while spermatogonia alter RNA splicing.