Christian Schmid, Muhammad Haziq ... Santiago Jaramillo
Mice learn a categorization task faster when exposed to task-relevant stimuli outside training, supporting neural-network models in which unsupervised learning first captures the statistical structure of inputs before classifying them.
By binding to TRAIL and inducing its oligomerization, heparan sulfate plays a role in regulating the pro-apoptotic activity of TRAIL towards several types of tumor cells.
Cross-frequency communication between the cortex and thalamus is linked to consciousness and changes in unconscious and psychedelic states, possibly due to shifts in brain dynamics between stability and chaos.
New P-glycoprotein structures reveal a substrate translocation mechanism and pathway across lipid bilayers that challenges ATP-binding cassette transporter norms.
Amruta Tendolkar, Anyi Mazo-Vargas ... Arnaud Martin
CRISPR knock-outs and functional genomic approaches probe the regulatory mechanism restricting the Hox gene Ubx to butterfly hindwings, explaining color pattern differentiation from forewings.
Jennifer K Briggs, Anne Gresch ... Richard KP Benninger
The functional network of β-cells in the pancreatic islet, which has been used to identify important subpopulations of β-cells implicated in diabetes progression, is indicative of intrinsic dynamics rather than structural communication, implying islet robustness.
Adriano R Lameira, Madeleine E Hardus ... Marco Gamba
Wild male orangutans produce long calls composed of two hierarchical layers, wherein isochronous sub-pulses occur within isochronous pulses, indicating that recursive vocal combinatorics are not exclusive to language among hominids.
Sequential expression of two transcription factors that bind to five- and ten-base female-specific cis-acting elements, respectively, promotes differentiation of Plasmodium female gametocytes.
Fabio Lolicato, Julia P Steringer ... Walter Nickel
Disulfide-bridged fibroblast growth factor 2 (FGF2) dimerization at the inner plasma membrane leaflet produces the building block for higher FGF2 oligomers that drive FGF2 membrane translocation into the extracellular space.
