Browse our Research Articles

Page 236 of 1,418
    1. Neuroscience

    Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens

    Yi He, Yanhua H Huang ... Yan Dong
    Two distinct projections from the basolateral amygdala to nucleus accumbens differentially contribute to cue- versus reward-mediated behavioral reinforcement.
    1. Neuroscience

    Approach-avoidance reinforcement learning as a translational and computational model of anxiety-related avoidance

    Yumeya Yamamori, Oliver J Robinson, Jonathan P Roiser
    A computational and translational approach to measuring anxiety-related behaviour was validated in two large independent samples, presenting opportunities for cross-species anxiety research and potential implications for anxiolytic drug development.
    1. Structural Biology and Molecular Biophysics

    Mechanism of substrate binding and transport in BASS transporters

    Patrick Becker, Fiona Naughton ... Alexander D Cameron
    The putative substrate pantoate binds to a sodium-coupled secondary transporter of the bile acid sodium symporter family, with sodium-dependent binding and conformational changes consistent with an elevator mechanism of transport.
    1. Epidemiology and Global Health

    The impact of COVID-19 on cancer screening and treatment in older adults: The Multiethnic Cohort Study

    Victoria P Mak, Kami White ... Loic Le Marchand
    During the COVID-19 pandemic, cancer-related screening and healthcare practices varied (by age, race/ethnicity, education, and comorbidities), and considering these differences in high-risk individuals' monitoring is important as undiagnosed cases or poor prognosis may increase due to delayed screening/treatment.
    1. Neuroscience

    Homeostatic control of deep sleep and molecular correlates of sleep pressure in Drosophila

    Budhaditya Chowdhury, Lakshman Abhilash ... Orie Shafer
    Controlling for the effects of mechanical stimulation during sleep deprivation reveals substantial multi-cycle sleep rebound in Drosophila and reveals serotonin as a potential sleep substance in the fly brain.
    1. Developmental Biology

    Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung

    Akihiro Miura, Hemanta Sarmah ... Munemasa Mori
    The Foxa2 lineage-based organ generative strategy allows us to establish a unique paradigm for the simultaneous generation of functional whole lungs and thymus, which can be applied to future transplantation therapy.
    1. Developmental Biology
    2. Plant Biology

    The Arabidopsis SHORTROOT network coordinates shoot apical meristem development with auxin-dependent lateral organ initiation

    Elmehdi Bahafid, Imke Bradtmöller ... Rüdiger GW Simon
    Mutant and gene expression analyses shows that phytohormones and mobile transcription factors interact to coordinate organ formation with stem cell maintenance in the plant shoot meristem.
    1. Computational and Systems Biology

    Identification of a carbohydrate recognition motif of purinergic receptors

    Lifen Zhao, Fangyu Wei ... Xi Cheng
    Computational models and mutagenesis study reveal a conserved carbohydrate recognition motif of two therapeutically important purinergic receptors to help understand the carbohydrate regulation of G-protein coupled receptors.
    1. Cancer Biology

    Molecular portraits of colorectal cancer morphological regions

    Eva Budinská, Martina Hrivňáková ... Vlad Popovici
    Tumor morphological patterns are linked to distinct transcriptional profiles and may indicate the need for a multi-site tumor sampling in gene expression-based studies.
    1. Neuroscience

    Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling

    Sehrish Javed, Ya-Ting Chang ... Wei-Hsiang Huang
    RAI1 regulates molecular signalling and intrinsic excitability of hypothalamic brain-derived neurotrophic factor neurons important for energy homeostasis.