Cancer-directed treatment using Tumor-Treating Fields spatially modulates the tumor microenvironment at the cellular and molecular levels, decreasing nanotube-based cellular networks of communication while creating a microenvironment more susceptible to immunotherapeutic strategies.
David J Harning, Samuel Sacco ... Gifford H Miller
Following the last deglaciation in the North Atlantic, DNA evidence shows Betulaceae colonization was consistently delayed compared to Salicaceae, which may serve as an analog for modern global warming.
Juvenile and adult metabolism are constrained from evolving independently from each other even in a species that lacks developmental continuity between juvenile and adult organs.
Gayathri Nagaraj, Shaveta Vinayak ... Dimpy P Shah
Sociodemographic (age, race/ethnicity) and clinical (Eastern Cooperative Oncology Group performance status, pre-existing comorbidities, and active and progressing cancer) risk factors were associated with worse COVID-19 outcomes in patients with breast cancer.
A complex colour polymorphism which links colour with behavioural and life-history traits is associated with a single gene duplication in male wood tiger moths.
Christopher T Boughter, Martin Meier-Schellersheim
A comprehensive computational study of germline-encoded T cell receptor CDR loops and MHC alpha-helices finds limited evidence for evolutionary conserved interactions, and instead suggests broad biophysical compatibility guides the interactions between the two proteins.
Genome-intact HIV-1 proviruses were detected in autopsy samples from the brain of ART-treated persons living with HIV, indicating that the virus can persist in the central nervous system.
