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Ventral premotor mirror neurons discriminate observed actions well but predominantly differently from self-performed actions, requiring reconsideration of concepts addressing their function.

The dendrite branching receptor HPO-30 modulates actin dynamics by binding to both WAVE complex and actin filaments.

Preventing activity of the kinase tumor progression locus 2 modulates microglial activation, reduces T-cell brain infiltration, and is neuroprotective in disease models.

A combination of electrophysiological, electrochemical, and anatomical experiments sheds new light on how the complex neurotransmitter repertoire of dopaminergic neurons in the brain is regulated by proteins of the neurexin family.

GABAergic interneurons coordinate synchronous muscle contractions along the length of the fruit fly larva to control the duration between peristaltic waves and locomotion speed.

A colloid fractal cluster model provides a quantitative link between the atomistic features of an intrinsically disordered polypeptide and the spatial organization of the biomolecular condensate it forms.

Specific inhibition of cyclin-dependent kinase-like 5 (CDKL5), a kinase linked to a severe neurodevelopmental disorder, demonstrates an important role in the regulation of excitatory hippocampal synapses and synaptic plasticity that was not previously appreciated in rodent knock-out models.

Binding of the second messenger inositol 1,4,5-trisphosphate to its intracellular receptor drives interaction between the intracellular Ca2+ sensor STIM and the plasma membrane localized Ca2+ channel Orai and raises the level of store-operated Ca2+ entry in mammalian cells.

The small, highly conserved transmembrane protein disrupted in zebrafish dreammist mutants regulates the activity of the sodium-potassium pump, leading to changes in sleep behaviour.

Mitochondria serve as a reservoir for the sorting of an miRNA into P-bodies and from there into exosomes secreted from human cultured cells.