Browse our Research Articles

Page 250 of 1,459
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Activity of MukBEF for chromosome management in E. coli and its inhibition by MatP

    Mohammed Seba, Frederic Boccard, Stéphane Duigou
    MukBEF selectively loads onto newly replicated DNA, and MatP prevents MukBEF activity, correlating with matS sites, likely due to MatP-mediated unloading.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Identification of 1600 replication origins in S. cerevisiae

    Eric J Foss, Carmina Lichauco ... Antonio Bedalov
    Replication origins in yeast are more widespread than previously believed.
    1. Stem Cells and Regenerative Medicine

    Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells

    Matias I Autio, Efthymios Motakis ... Roger SY Foo
    Depiction of novel human genomic safe harbour loci that have been validated in vitro for safety and stable expression in human embryonic stem cells and cell types from all the three germ lineages.
    1. Immunology and Inflammation

    Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

    Rabina Mainali, Nancy Buechler ... Matthew A Quinn
    Proteomic-based discovery of a novel mechanism of action affording anti-steatotic properties of itaconate through stabilization of fatty acid oxidation enzyme protein abundance.
    1. Developmental Biology

    Intrinsic and extrinsic cues time somite progenitor contribution to the vertebrate primary body axis

    Lara Busby, Guillermo Serrano Nájera, Benjamin John Steventon
    Cells know when to contribute to the maturing embryonic body axis by adjusting an internal timer to the conditions around them.
    1. Microbiology and Infectious Disease

    Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans

    Yang Meng, Yue Ni ... Chen Ding
    Isw1 acts as a master regulator in modulating the expression of drug-resistance genes, and this regulatory mechanism is dependent on the interaction of Isw1 acetylation and ubiquitination.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The seminal odorant binding protein Obp56g is required for mating plug formation and male fertility in Drosophila melanogaster

    Nora C Brown, Benjamin Gordon ... Mariana Federica Wolfner
    A functional genetics approach reveals a novel role for odorant binding proteins in post-mating processes, with complex mechanisms of evolutionary change across closely related insect species.
    1. Neuroscience

    Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility

    Reto B Cola, Diana M Roccaro-Waldmeyer ... Marco R Celio
    Foxb1-expressing hypothalamic neurons in the parvafox nucleus and the dorsal premammillary nucleus both contribute to behavioral and physiological components associated with defensive behavior.
    1. Immunology and Inflammation

    Activation of the P2RX7/IL-18 pathway in immune cells attenuates lung fibrosis

    Serena Janho dit Hreich, Thierry Juhel ... Valerie Vouret-Craviari
    The use of a small activator of P2RX7 highlights the importance of the P2RX7 pathway to enhance the antifibrotic properties of lung immune cells.
    1. Microbiology and Infectious Disease

    Dynamics of macrophage polarization support Salmonella persistence in a whole living organism

    Jade Leiba, Tamara Sipka ... Mai E Nguyen-Chi
    Real-time visualization of Salmonella enterica and polarized macrophage interaction in the living host identifies an anti-inflammatory, pro-regenerative, and motionless macrophage subset as a survival niche during persistent infection.