Browse our Research Articles

Dual function of promyelocytic leukemia nuclear bodies (PML NBs) acting as buffering centers modulating the nuclear distribution of HIRA, and as chromosomal hubs regulating interferon-stimulated genes (ISGs) transcription, and thus HIRA-mediated H3.3 deposition/recycling at ISGs upon inflammatory response.

Sodium selenate is the first treatment with persistent disease-modifying effects reducing seizures and improving cognitive deficits, in chronically epileptic and drug-resistant TLE animals.

Missense mutations in the nuclear-encoded adenine nucleotide translocase 1 (Ant1) cause the protein to clog the mitochondrial protein import pathway, to severely inhibit cell growth in yeast, and to cause neurodegeneration and myopathy in mice that phenocopy ANT1-induced human disease.

Alveolar type 2 stem cells are actively maintained by Hippo signaling and Taz promotes alveolar epithelial regeneration and the resolution of bleomycin induced pulmonary fibrosis upon inactivation of the Hippo pathway in Alveolar type 2 stem cells.

The genomic features associated with a gene fate to loss have been retained for approximately 500 million years during evolution, and the genes with these features exhibit restricted expression profiles, leading to the genes being less important.

The pulsatile activities of kisspeptin neurons, the central pacemaker activities of reproductive functions, show unexpected robustness in terms of frequency, but a tendency for the intensity to decline, during the transition to reproductive senescence in mice.

Metabolites, such as acylcarnitines, accumulate in Drosophila heads when endocytosis is blocked and reflects an increased need for sleep.

Muscle synergies are able to identify muscular adaptation that results from feelings of joint instability, whereas tibiofemoral kinematics are sensitive for detecting acute instability events during functional activities.

Responses of monkeys, rats, and humans performing perceptual discrimination of discrete-sample stimuli rely on accumulation over time of sensory evidence.

Transcriptomic, enzyme activity, and flux data demonstrate that metabolic scaling, the inverse correlation between body size and metabolic rate per gram of tissue, is a conserved phenomenon that occurs at multiple physiological levels and in multiple tissues.