Browse our Research Articles

Page 251 of 1,392
    1. Neuroscience

    Brain and molecular mechanisms underlying the nonlinear association between close friendships, mental health, and cognition in children

    Chun Shen, Edmund T Rolls ... Jianfeng Feng
    Close friend quantity is nonlinearly associated with various mental health and cognitive outcomes in children and could be partly explained by the structure of the social brain and the endogenous opioid system.
    1. Computational and Systems Biology
    2. Neuroscience

    Flexible control of representational dynamics in a disinhibition-based model of decision-making

    Bo Shen, Kenway Louie, Paul Glimcher
    Local disinhibition provides a biologically plausible mechanism for flexible top-down control of network states that integrates normalized value coding, winner-take-all choice, and persistent activity in a single circuit of decision-making.
    1. Cancer Biology
    2. Structural Biology and Molecular Biophysics

    Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

    Jean-Philippe Defour, Emilie Leroy ... Stefan N Constantinescu
    Structural and functional analyses reveal the general mechanism of activation of the thrombopoietin receptor and unravel the critical role of W515.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates

    Adele Francis Xu, Rut Molinuevo ... Maria Barna
    Ribosomal proteins Rps27 (eS27) and Rps27l (eS27L) are an ancient pair of duplicated genes that encode functionally interchangeable proteins, yet have been evolutionarily retained because both copies are necessary to achieve protein expression across cell types.
    1. Neuroscience

    A stable, distributed code for cue value in mouse cortex during reward learning

    David J Ottenheimer, Madelyn M Hjort ... Garret D Stuber
    Individual neurons in a surprising number of frontal cortical regions encode the value of reward-predicting olfactory cues across distinct stimulus sets and experimental sessions.
    1. Microbiology and Infectious Disease

    Bacterial DNA on the skin surface overrepresents the viable skin microbiome

    Ellen M Acosta, Katherine A Little ... Zemer Gitai
    The bacterial DNA on the surface of human and mouse skin is primarily from dead bacteria while viable skin microbiome bacteria mostly colonize subsurface skin structures like hair follicles.
    1. Evolutionary Biology
    2. Genetics and Genomics

    On the limits of fitting complex models of population history to f-statistics

    Robert Maier, Pavel Flegontov ... David Reich
    Many published findings about population history that rely on inference of admixture graph models fitted to f-statistics are not robust since the method is generally inappropriate for extracting new information about population history.
    1. Computational and Systems Biology
    2. Neuroscience

    Model discovery to link neural activity to behavioral tasks

    Jamie D Costabile, Kaarthik A Balakrishnan ... Martin Haesemeyer
    Model identification of neural encoding is an accessible system for the analysis of neural data that allows identifying and characterizing arbitrary relationships between neural activity and task-related variables such as behavior, stimuli, or internal states.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A

    Roberta Cacioppo, Hesna Begum Akman ... Catherine Lindon
    Post-transcriptional regulation of Aurora Kinase A (AURKA) through alternative polyadenylation of its mRNA determines miRNA influence and is a feature of cell cycle-specific AURKA expression whose impairment leads to acquisition of cancer phenotypes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Joint inference of evolutionary transitions to self-fertilization and demographic history using whole-genome sequences

    Stefan Strütt, Thibaut Sellinger ... Stefan Laurent
    Transitions from outcrossing to selfing, a major shift in mating systems, create a specific signature in intra-specific genetic polymorphisms, which can be used to infer the demographic history of populations and acquire valuable insights about the evolution of recombination rates.