Optogenetic climbing fiber activation regulates experience-dependent plasticity in the primary somatosensory cortex of mice, suggesting a role of the olivo-cerebellum in instructive signaling across brain regions.
Marta Wojnowska, Takeaki Wajima ... Ulrich Schwarz-Linek
The T-shaped fold of an abundant surface protein ties streptococci to collagens, an interaction that enhances biofilm such as often found in invasive infections.
Up-to-date computational pipeline characterizes G-protein-coupled receptor (GPCR) repertoires in the closest relatives of metazoans, providing a framework to investigate the evolutionary origins and ancestral functions of key metazoan signaling pathways.
Franka H van der Linden, Stephen C Thornquist ... Joachim Goedhart
Directed evolution was used to engineer a green fluorescent biosensor for quantitative calcium imaging that remains fluorescent, yet shows a large change in lifetime in cells.
Deletion of specific herpes simplex virus proteins prevents the progression of virus assembly at discrete stages, allowing detailed 3D imaging of rare events in the morphogenesis of virus particles.
Testosterone promotes the conversion of glucose to fatty acids by increasing the expression of ACLY in seminal vesicle epithelial cells, thereby regulating the seminal plasma components.
Genes steadily associated with prognosis define conserved mitotic and immune programs that robustly predict cancer patient survival and therapeutic resistance across tumor types.
Extracellular adenosine deamination by ADGF generates ammonia that directs tip organizer development, revealing a conserved metabolic mechanism linking nucleotide turnover to developmental regulation.
