Elevated ubiquitin phosphorylation disrupts proteasomal function, creating a self-amplifying cycle that drives progressive protein aggregation and neuronal injury across multiple neurodegenerative conditions.
The promotion of C1QBP accumulation by PA28γ leads to the malignant progression of tumor by affecting mitochondrial function, which could be a launch pad for therapeutic intervention of tumor development.
Márton Kajtor, Viktor András Billes ... Balázs Hangya
An inexpensive, scalable trial-based behavioral assay revealed quantitative difference in fruit flies' escape behavior across different genetic models of neurodegeneration.
Alaknanda Emery, Orest W Blaschuk ... Darryl L Russell
A critical role for N-cadherin in ovarian follicular development and ovulation is demonstrated with inhibitors or knockout of N-cadherin shown to inhibit ovulation by blocking mechanotransduction of ovulatory genes.
Giorgio Nicoletti, Matteo Bruzzone ... Daniel Maria Busiello
The onset of habituation phenomena enables accurate processing of external stimuli when biological systems adapt their parameters to balance dissipation and the information between input and response.
Markus Borud Pettersen, Vemund Schøyen ... Mikkel E Lepperød
Border cells are sufficient to generate place cells and remapping during path integration in artificial neural networks, challenging the role of grid cells for spatial navigation.
Wesley H Godfrey, Judy J Lee ... Michael D Kornberg
The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanced than previously appreciated.
Neoadjuvant SBRT with dalpiciclib and exemestane resulted in a 16.7% RCB 0-I rate and a 91.7% ORR, with acceptable toxicities in HR-positive, HER2-negative breast cancer patients.
