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High-content high-resolution microscopy coupled with deep learning-based analysis reveals novel phenotypes at the single-cell level during Shigella infection.

Archaeal cells mix single-headed and double-headed lipids to construct resilient but flexible membranes to help them survive in extreme environments.

Machine learning with whole-cell patch-clamp and local field potential recordings reveals that synaptic responses from five mossy cells, despite their limited population, can significantly reconstruct about 30% of the total hippocampal sharp wave-ripples, highlighting efficient distributed coding within subthreshold activities.

Social enrichment increases the less-frequent high-intensity aggressive tussling and decreases the low-intensity aggressive lunging via distinct sensory and central neurons.

A sequence-based method, DIRseq, has been developed to predict drug-interacting residues of intrinsically disordered proteins.

The first follicle wave undergoes atresia to amplify androgen-producing theca cells, while previously unknown wave 1.5 follicles leave quiescence at 2 weeks and produce most of the earliest offspring.

The dorsal vagal complex is a highly intricate structure composed of distinct transcriptional classes of glial and neuronal cells, exhibiting many similarities but also notable differences between mice and rats.

Rapid, combined and personalized non-invasive stimulation of the precuneus improves associative memory, enhances local gamma expression, and strengthens precuneus–hippocampal connectivity.

Individual retinal ganglion cells are singularly activated in the living primate retina via an adaptive optics scanning light ophthalmoscope.

Widespread sex-dimorphic transcriptomic changes during human aging in pan-tissues scale reveal distinct molecular aging trajectories and potential links to age-related disease vulnerability.