Glycogen engineering strategies of mammalian cells were developed, which improved the survival of mesenchymal stem cells post-implantation and their therapeutic efficacy in pulmonary fibrosis model.
Mouse embryo cells undergo apical-basal polarization asynchronously at the 8-cell stage, and the timing of polarization influences subsequent lineage allocation.
Holographic neuronal stimulation shows that auditory cortex neurons with shared functional properties rapidly adjust their responses during sensory processing, revealing a circuit-level mechanism that regulates overall network activity balance.
Dana Thornlow Lamson, Faez Amokrane Nait Mohamed ... Aaron G Schmidt
BOAS is a platform for building multivalent viral protein immunogens without a scaffold, such as a nanoparticle, to elicit broad influenza vaccine responses.
Theoretical and computational modeling reveals a mechanism of active patterning of uniform isotropic actin gels into dense nematic bundles, providing a physical basis for the adaptability of the actin cytoskeleton.
Binayak Sarkar, Jyotsna Singh ... Rajesh S Gokhale
In vitro, ex vivo, and in vivo studies reveal that hepatocytes are significantly infected by Mycobacterium tuberculosis which rewires the host cell metabolism to upregulate the lipid biosynthetic pathways.
Iryna Schommartz, Philip F Lembcke ... Yee Lee Shing
Children show less robust memory retention overnight and after 2 weeks, with memories transforming more rapidly from detailed to gist-like neural representations, revealing less stable consolidation mechanisms than in adults.
Quantitative Drosophila pupal wing experiments support planar polarity depending on cell-scale signalling that does not involve depletion of a limited pool of core proteins or polarised transport on microtubules.
