KLF2 activity and impaired interferon signaling contribute to HIV-1 persistence by restricting antiviral immunity in infected CD4 T cells during early infection.
COMMD3 regulates endosomal trafficking outside the Commander holo-complex, revealing that a trafficking complex subunit can function independently of the entire complex.
Disrupting full-length BEND2 impairs ovarian reserve establishment without causing male sterility, highlighting a sex-specific role in fertility and offering new insights into genetic contributions to infertility diagnosis and reproductive health.
The substantia nigra inhibits all PPN neurons and causes place aversion, while the globus pallidus selectively inhibits caudal non-cholinergic PPN neurons and causes place preference.
Souleymane Diallo, Kateřina Kašparová ... Robert Hanus
Identification of the trail-following pheromone receptor in the termite Prorhinotermes simplex represents the first functional characterization (deorphanization) of an odorant receptor in termites.
Maria Ardaya, Marie-Catherine Tiveron ... Fabio Cavaliere
A population of ischemia-induced newborn astrocytes, positive for Thbs4, that migrate to the lesion border, where they produce and degrade hyaluronan, modulating the local extracellular matrix, has been identified.
Bing Guo, Shannon Takala-Harrison, Timothy D O'Connor
hmmIBD outperforms alternative tools in detecting genome segments that are identical-by-descent and uncovering signals of positive selection and demographic history in malaria parasite genomes, underscoring the importance of tool prioritization and optimization for reliable malaria genomic surveillance.
The cryoEM structure of a RAD51 displacement loop reveals the molecular mechanism of the strand-exchange reaction at the centre of eukaryotic homologous recombination.
Thomas Balligand, Claire Carpenet ... Maarten Dewilde
Two radio-labeled nanobodies and a single knock-in mouse model suffice to track the biodistribution of various unmodified cell-types in live mice by PET/CT.
