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Full-length single-cell RNA-sequencing provide insights into the earliest gene expression programs, the distinct mRNA transcript isoforms, and the retinoblastoma-related cell states associated with human cone and rod photoreceptor development.

The majority of TMEM16 lipid scrambling occurs in the open groove associated with Ca²⁺ activation, but limited scrambling also occurs in the dimer interface independent of Ca²⁺.

Keratinocyte cytonemes mediate essential Notch signaling for proper skin maintenance, with their disruption leading to abnormal differentiation and hyperproliferation resembling human skin disease phenotypes.

Exercise intensity alone does not differentially reduce pain, but individual factors like fitness level and sex, along with opioid mechanisms, may influence exercise-induced pain relief.

Fine-grained neural dynamics underlying speech coordination are revealed using a real-time interactive synchronous speech task that dissociates functional roles within the dorsal language pathway.

Kallistatin acts as a key regulator in mediating Aβ accumulation and tau hyperphosphorylation in AD.

Odors directly activate taste neurons in Drosophila, revealing a peripheral mechanism of odor-taste integration that enhances feeding behavior.

Srs2 binding to PCNA and subsequent Mec1-dependent sumoylation regulate RPA-mediated checkpoint signaling.

Increasing CD11c⁺ microglial subsets in the spinal dorsal horn by intrathecal treatment of interleukin-4 alleviate pain hypersensitivity caused by nerve injury.

Genetic analyses in zebrafish reveal a new role for the Meteorin protein family in the left-right asymmetry patterning during embryonic vertebrate development.