Bárbara Pinto-Correia, Patrícia Caldeira-Bernardo, Miguel Remondes
Light-activating a proton pump (eArchT) to silence hippocampal synaptic terminals in the rodent retrosplenial cortex caused a spatial working memory impairment affecting interleaved trials where no light was delivered.
The complete synaptic connectome and the comprehensive annotation of all cell types based on a whole-body electron microscopy volume of an annelid larva.
NOLC1 inhibits p53 nuclear accumulation and transcription, subsequently suppresses cisplatin-induced ferroptosis, and promotes an immunosuppressive microenvironment, eventually suppressing immunochemotherapy in gastric cancer.
Clinical, genetic, and model organism data collectively define PLCG1 as a disease-associated gene with diverse missense variants contributing to phenotypic heterogeneity.
Laura Dovek, Mahboubeh Ahmadi ... Vijayalakshmi Santhakumar
Evaluation of semilunar granule cell involvement in dentate gyrus contextual memory processing supports recruitment based on intrinsic and input characteristics while revealing limited contribution to ensemble refinement.
The unbiased genetic screening and animal model experiments have characterized a new candidate pathogenic gene associated with high myopia, providing a potential therapeutic intervention target for controlling the disease.
Molecular chirality of actomyosin induces cell-scale chiral rotation without requiring a chiral arrangement of actomyosin filaments, revealing a key mechanism of cell chirality underlying left–right asymmetric tissue development.
