Kayson Fakhar, Fatemeh Hadaeghi ... Claus C Hilgetag
A game-theoretical framework for uncovering how optimal signal transmission takes place in a given network, here applied to large-scale brain networks.
Diet-induced obesity, insulin resistance, and proinflammatory macrophage activation and accumulation in adipose tissue can be counteracted through the inhibition of ER stress sensor IRE1alpha.
Chitons overcome evolutionary constraints through unprecedented genomic dynamism, with extensive chromosomal rearrangements and duplications despite about 300 million years of morphological stasis.
Kinetic measurements of kinesin-1's front and rear heads reveal how different neck linker orientation regulate their activity, enabling the motor protein to move in a coordinated manner along microtubules.
Sexually antagonistic pleiotropy involving frequency-dependent traits like mating display maintains linkage blocks like inversions as balanced polymorphisms in simulation, and may explain common inversion polymorphisms maintained at intermediate frequencies.
Hirokazu Kimura, Kamel Lahouel ... Nicholas Jason Roberts
High-throughput characterization of all possible CDKN2A missense variants identifies functionally deleterious variants and establishes accuracy of variant effect predictors.
Future prosocial acts can be forecasted from stable biological differences in how people perceive others' merit, pointing to novel strategies to reduce favoritism and discrimination in social situations.
Phillip P Witkowski, Lindsay JH Rondot ... Erie Boorman
Orbitofrontal cortex and hippocampus reinstate representations of causal choices to associate with delayed outcomes, and the frontal pole supports this credit assignment process by maintaining pending choices during interim decisions.
