There is no discernible effect of an additional year of education from a policy change on long-term structural neuroimaging measures in a large aging sample (UK Biobank).
Aurore Thomazeau, Sabine Rannio ... Per Jesper Sjöström
Neocortical timing-dependent LTD relies on non-ionotropic presynaptic NMDA receptor signaling via JNK2, challenging the textbook view that NMDA receptors are ionotropic coincidence detectors in Hebbian plasticity.
Homotypic olfactory receptor neurons in Drosophila, including CO2-sensing neurons with distinctive sheet-like dendrites, exhibit unexpected morphological diversity that may underlie functional adaptability.
A single-cell transcriptomic study characterizes foxl2l-expressing germ cell progenitors important for female development in zebrafish and reveals the mechanism of sex differentiation.
Analyses of zebrafish meioc mutants revealed that spermatogonial stem cells with low rRNA transcription caused by nucleolar Piwil1 require Meioc to keep Piwil1 in cytoplasm for the upregulation of rRNA transcription necessary for differentiation.
Uncovering a novel PDE1A/YTHDF2/STAT3 pathway in non-small cell lung cancer (NSCLC) progression also provides therapeutic strategies for treating NSCLC patients with metastasis.
Genetic analysis of Streptococcus pyogenes reveals multiple mutations, including a key change in the fhuB gene, that influence the bacteria’s ability to cause severe invasive infections.
Ozanna Burnicka-Turek, Katy A Trampel ... Ivan P Moskowitz
Coordinated removal of Tbx3 and Tbx5 function alters the molecular features of the fast ventricular cardiac conduction system toward non-conduction working myocardium, illuminating transcriptional control of cardiac conduction system patterning.
