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A hitherto unrecognized superfamily of enzymes identified here provides unifying insights spanning lipid metabolism, anti-viral and anti-bacterial immunity, and the origin of developmental regulators like Wnt.

Inhibition of the endothelin B receptor (ETBR) with FDA-approved Bosentan enhances axon regeneration and reverses age-related decline, revealing a promising therapeutic target for improving nerve repair in older individuals.

Gut-to-brain communication via glial cytokine signaling links intestinal oxidative stress to altered sleep patterns, highlighting how gut inflammation can influence brain function and restorative sleep behaviors essential for mental well-being.

Discovery of calcarins in calcareous sponges highlights gene duplication and neofunctionalization as drivers of parallel biomineralization, offering insight into the independent evolution of calcification in early-diverging animals.

fMRI decoding reveals that the inferior frontal junction-visual network reinstates target-related information as a proxy for target localization before visual search.

The kinase activity of Aurora kinase A is required for preserving S-adenosylmethionine availability for histone methylation and epigenetic reprogramming during trained immunity induction in macrophages.

The crystal structure of Sld3CBD-Cdc45 shows its intermolecular interactions, and subsequent Sld3CBD-CMG model construction and binding assays enable a proposal for the mechanism of Cdc45 recruitment and Sld3 release.

Ten-microsecond atomistic simulations directly capture the voltage activation of the Core-MT big potassium channel, revealing novel voltage sensing and sensor-pore coupling mechanisms that have largely eluded the community.

The accessory genome of Mycobacterium tuberculosis is small, but differences in gene content are found both between and within lineages.

In Pseudomonas aeruginosa, the chemoreceptor cluster and flagellar motor colocalize at the same cell pole through FlhF anchoring, preventing cross-pathway signaling interference between chemotaxis and c-di-GMP regulation.