Browse our Research Articles

Page 29 of 1,419
    1. Developmental Biology

    Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona

    Akiko Hozumi, Nozomu M Totsuka ... Yasunori Sasakura
    Ascidian larvae use cAMP as the molecular timer to infer the timing initiating metamorphosis.
    1. Neuroscience

    A causal role of the NMDA receptor in recurrent processing during perceptual integration

    Samuel Noorman, Timo Stein ... Simon van Gaal
    Memantine selectively improves neural decoding of attended illusory contours, revealing NMDA receptor-dependent enhancement of feedback processing in human visual perception.
    1. Stem Cells and Regenerative Medicine

    PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

    José Antonio Valer, Alexandre Deber ... Francesc Ventura
    PI3Kα inhibitors show promise as therapeutic agents for the treatment of heterotopic ossification.
    1. Cancer Biology

    Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer

    Xin Zhang, Guangyu Zhang ... Chunjie Liu
    iCAF-mediated immune escape and promoted tumor angiogenesis via VEGFA/B-VEGFR1 pathway indicate that a combination of immunotherapies and anti-angiogenic targeted therapy may be effective for H. pylori infection-associated gastric cancer.
    1. Developmental Biology

    Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling

    Joseph Hanna, Yacine Touahri ... Carol Schuurmans
    Transgenic and pharmacological approaches reveal developmental elevations in glycolytic flux have an instructive role in promoting rod photoreceptor differentiation and maturation via activation of Wnt signaling.
    1. Neuroscience

    A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality

    Seetha Krishnan, Can Dong ... Mark Sheffield
    A novel virtual reality-based contextual fear conditioning paradigm for head-fixed mice that elicits robust freezing behavior and enables multiphoton imaging of neural circuits underlying learning, memory, and fear.
    1. Cell Biology
    2. Neuroscience

    Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons

    Masaya Muramoto, Nozomi Hanawa ... Natsuki Shinoda
    Subcellular sequestration of caspase near membrane-associated proteins enables its non-lethal activation, which modulates neuronal function and innate olfactory behavior in the adult Drosophila olfactory receptor neurons.
    1. Neuroscience

    Morphology and ultrastructure of external sense organs of Drosophila larvae

    Vincent Richter, Anna Rist ... Andreas S Thum
    Advanced electron microscopy techniques have been applied to comprehensively describe the cellular details and ultrastructural characteristics of all sensilla within the external sensory system of Drosophila larvae.
    1. Microbiology and Infectious Disease

    Stumpy forms are the predominant transmissible forms of Trypanosoma brucei

    Jean Marc Tsagmo Ngoune, Parul Sharma ... Brice Rotureau
    According to experimental and field observations, stumpy forms appear to be the most adapted forms for African trypanosome transmission from the mammalian host to the tsetse fly in natural conditions.
    1. Neuroscience

    Four individually identified paired dopamine neurons signal taste punishment in larval Drosophila

    Denise Weber, Katrin Vogt ... Andreas S Thum
    A neurogenetic approach reveals the cellular division of labor between individual Drosophila larval dopaminergic neurons encoding an averive teaching signal, reflecting principles in the adult insect and vertebrate brain.