The flexible stalk region of sTREM2 binds the Ig-like domain, altering stability and ligand accessibility—a biochemically testable mechanism with broad implications for (s)TREM2 biology and rational Alzheimer's disease therapeutic design.
Primate cross-species analysis of interactions between transposable elements and KRAB-ZNF genes with the new TEKRABber tool highlights human-specific interactions with potential relevance to Alzheimer’s disease.
Jessica A Haley, Tianyi Chen ... Sreekanth H Chalasani
C. elegans foraging decisions are guided by learned environmental features, integrating recent patch quality with internal satiety to balance exploration and exploitation.
Huei-Bin Wang, Natalie E Smale ... Christopher S Colwell
These findings provide convincing evidence of the beneficial effects that restored biological rhythms may have on disease pathophysiology and symptoms.
Grafting surface loops containing antibody epitopes of a poorly expressed flu neuraminidase protein onto a high-expressing, stable scaffold improves its production and stability for vaccine development.
A Maxwell Burroughs, Gianlucca G Nicastro, L Aravind
A hitherto unrecognized superfamily of enzymes identified here provides unifying insights spanning lipid metabolism, anti-viral and anti-bacterial immunity, and the origin of developmental regulators like Wnt.
Inhibition of the endothelin B receptor (ETBR) with FDA-approved Bosentan enhances axon regeneration and reverses age-related decline, revealing a promising therapeutic target for improving nerve repair in older individuals.
